Construction and analysis of a human-chimpanzee comparative clone map

被引：184

作者：

Fujiyama, A

Watanabe, H

Toyoda, A

Taylor, TD

Itoh, T

Tsai, SF

Park, HS

Yaspo, ML

Lehrach, H

Chen, Z

Fu, G

Saitou, N

Osoegawa, K

de Jong, PJ

Suto, Y

Hattori, M

Sakaki, Y

机构：

[1] RIKEN, Genom Sci Ctr, Tsurumi Ku, Kanagawa 2300045, Japan

[2] Natl Inst Genet, Shizuoka 4118450, Japan

[3] Mitsubishi Res Inst, Chiyoda Ku, Tokyo 1008141, Japan

[4] Natl Yang Ming Univ, Taipei 115, Taiwan

[5] Natl Inst Res Inst, Taipei 115, Taiwan

[6] KRIBB, Genome Res Ctr, Taejon 305333, South Korea

[7] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[8] Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China

[9] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA

[10] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan

[11] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Minato Ku, Tokyo 1088639, Japan

来源：

SCIENCE | 2002年 / 295卷 / 5552期

关键词：

D O I：

10.1126/science.1065199

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

引用

页码：131 / 134

页数：4

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