Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

被引:50
作者
Lauermann, Jost L. [1 ]
Eter, Nicole [1 ]
Alten, Florian [1 ]
机构
[1] Univ Munster, Dept Ophthalmol, Med Ctr, Domagkstr 15, DE-48149 Munster, Germany
关键词
Optical coherence tomography; Optical coherence tomography angiography; Spectral-domain optical coherence tomography; Swept-source optical coherence tomography; Choriocapillaris; Age-related macular degeneration; Central serous chorioretinopathy; CENTRAL SEROUS CHORIORETINOPATHY; PIGMENT EPITHELIAL DETACHMENT; MACULAR DEGENERATION; OCT-ANGIOGRAPHY; SWEPT-SOURCE; GEOGRAPHIC ATROPHY; SPECTRAL-DOMAIN; MORPHOMETRIC-ANALYSIS; ULTRAHIGH-SPEED; CHOROIDAL NEOVASCULARIZATION;
D O I
10.1159/000485261
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy. (c) 2018 S. Karger AG, Basel.
引用
收藏
页码:74 / 84
页数:11
相关论文
共 68 条
[1]   Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes [J].
Al-Sheikh, Mayss ;
Phasukkijwatana, Nopasak ;
Dolz-Marco, Rosa ;
Rahimi, Mansour ;
Iafe, Nicholas A. ;
Freund, K. Bailey ;
Sadda, SriniVas R. ;
Sarraf, David .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (04) :2063-2069
[2]   OCT angiography in the mouse: A novel evaluation method for vascular pathologies of the mouse retina [J].
Alnawaiseh, Maged ;
Rosentreter, Andre ;
Hillmann, Anja ;
Alex, Anne F. ;
Niekaemper, Daniel ;
Heiduschka, Peter ;
Pap, Thomas ;
Eter, Nicole .
EXPERIMENTAL EYE RESEARCH, 2016, 145 :417-423
[3]   Signal reduction in choriocapillaris and segmentation errors in spectral domain OCT angiography caused by soft drusen [J].
Alten, F. ;
Lauermann, J. L. ;
Clemens, C. R. ;
Heiduschka, P. ;
Eter, N. .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2017, 255 (12) :2347-2355
[4]   Exploring choriocapillaris under reticular pseudodrusen using OCT-Angiography [J].
Alten, Florian ;
Heiduschka, Peter ;
Clemens, Christoph R. ;
Eter, Nicole .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2016, 254 (11) :2165-2173
[5]   Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex [J].
Bhutto, Imran ;
Lutty, Gerard .
MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (04) :295-317
[6]   Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration [J].
Biesemeier, Antje ;
Taubitz, Tatjana ;
Julien, Sylvie ;
Yoeruek, Efdal ;
Schraermeyer, Ulrich .
NEUROBIOLOGY OF AGING, 2014, 35 (11) :2562-2573
[7]   Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration [J].
Bindewald, A ;
Schmitz-Valckenberg, S ;
Jorzik, JJ ;
Dolar-Szczasny, J ;
Sieber, H ;
Keilhauer, C ;
Weinberger, AWA ;
Dithmar, S ;
Pauleikhoff, D ;
Mansmann, U ;
Wolf, S ;
Holz, FG .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2005, 89 (07) :874-878
[8]   Association of Choroidal Neovascularization and Central Serous Chorioretinopathy With Optical Coherence Tomography Angiography [J].
Bonini Filho, Marco Antonio ;
de Carlo, Talisa E. ;
Ferrara, Daniela ;
Adhi, Mehreen ;
Baumal, Caroline R. ;
Witkin, Andre J. ;
Reichel, Elias ;
Duker, Jay S. ;
Waheed, Nadia K. .
JAMA OPHTHALMOLOGY, 2015, 133 (08) :899-906
[9]   Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration [J].
Borrelli, Enrico ;
Uji, Akihito ;
Sarraf, David ;
Sadda, SriniVas R. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (11) :4792-4798
[10]   Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography [J].
Campbell, J. P. ;
Zhang, M. ;
Hwang, T. S. ;
Bailey, S. T. ;
Wilson, D. J. ;
Jia, Y. ;
Huang, D. .
SCIENTIFIC REPORTS, 2017, 7