Tendinopathy and tendon injury: The future

被引:66
作者
Sharma, Pankaj [1 ]
Maffulli, Nicola [1 ]
机构
[1] Keele Univ, Sch Med, Dept Trauma & Orthopaed Surg, Stoke On Trent ST4 7LN, Staffs, England
关键词
Tendon healing; tendinopathy; gene therapy; physical modalities; mesenchimal stem cell therapy;
D O I
10.1080/09638280701788274
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Tendon disorders are debilitating, and difficult to manage. Current management strategies offer symptomatic relief, but do not result in definitive disease resolution. Despite remodeling, the biochemical and mechanical properties of healed tendon tissue may never match those of intact tendons. This article presents a detailed up-to-date review of possible strategies for optimizing tendon healing and repair, such as growth factor therapy, gene therapy, and tissue engineering.
引用
收藏
页码:1733 / 1745
页数:13
相关论文
共 166 条
[1]   Differential effects of insulin-like growth factor-I on matrix and DNA synthesis in various regions and types of rabbit tendons [J].
Abrahamsson, SO ;
Lohmander, S .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1996, 14 (03) :370-376
[2]   INVITRO FORMATION OF HYBRID FIBRILS OF TYPE-V COLLAGEN AND TYPE-I COLLAGEN - LIMITED GROWTH OF TYPE-I COLLAGEN INTO THICK FIBRILS BY TYPE-V COLLAGEN [J].
ADACHI, E ;
HAYASHI, T .
CONNECTIVE TISSUE RESEARCH, 1986, 14 (04) :257-266
[3]   Gene transfer into muscle by electroporation in vivo [J].
Aihara, H ;
Miyazaki, J .
NATURE BIOTECHNOLOGY, 1998, 16 (09) :867-870
[4]   COLLAGEN CROSS-LINKING ALTERATIONS IN JOINT CONTRACTURES - CHANGES IN REDUCIBLE CROSS-LINKS IN PERIARTICULAR CONNECTIVE-TISSUE COLLAGEN AFTER 9 WEEKS OF IMMOBILIZATION [J].
AKESON, WH ;
AMIEL, D ;
MECHANIC, GL ;
WOO, SLY ;
HARWOOD, FL ;
HAMER, ML .
CONNECTIVE TISSUE RESEARCH, 1977, 5 (01) :15-19
[5]  
AKESON WH, 1973, CLIN ORTHOP RELAT R, V93, P356
[6]   AN IN-VITRO INVESTIGATION INTO THE EFFECTS OF REPETITIVE MOTION AND NONSTEROIDAL ANTIINFLAMMATORY MEDICATION ON HUMAN TENDON FIBROBLASTS [J].
ALMEKINDERS, LC ;
BAYNES, AJ ;
BRACEY, LW .
AMERICAN JOURNAL OF SPORTS MEDICINE, 1995, 23 (01) :119-123
[7]   A biodegradable composite scaffold for cell transplantation [J].
Ameer, GA ;
Mahmood, TA ;
Langer, R .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2002, 20 (01) :16-19
[8]  
[Anonymous], RES EC INEQUALITY
[9]   Rabbit tendon cells produce MMP-3 in response to fluid flow without significant calcium transients [J].
Archambault, JM ;
Elfervig-Wall, MK ;
Tsuzaki, M ;
Herzog, W ;
Banes, AJ .
JOURNAL OF BIOMECHANICS, 2002, 35 (03) :303-309
[10]   Platelet concentrate injection improves Achilles tendon repair in rats [J].
Aspenberg, P ;
Virchenko, O .
ACTA ORTHOPAEDICA SCANDINAVICA, 2004, 75 (01) :93-99