Synthesis of Ribonuclease-A conjugated Ag2S quantum dots clusters via biomimetic route

被引：37

作者：

Chen, Jun ^{[1
]}

Zhang, Tao ^{[2
]}

Feng, Lili ^{[1
]}

Zhang, Meiqing ^{[1
]}

Zhang, Xin ^{[1
]}

Su, Haichung ^{[3
]}

Cui, Daxiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Inst Micro Nano Sci & Technol, Shanghai 200240, Peoples R China

[2] Fujian Acad Med Sci, Dept Immunol, Fuzhou 350200, Peoples R China

[3] Fourth Mil Med Univ, Tangdu Hosp, Dept Oncol, Xian 710038, Peoples R China

来源：

MATERIALS LETTERS | 2013年 / 96卷

基金：

中国国家自然科学基金;

关键词：

Biomaterials; Biomimetic; Luminescence; Quantum dots: Ag2S; SIZE;

D O I：

10.1016/j.matlet.2012.11.067

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Highly monodisperse and water-soluble Ribonuclease-A (RNase A) copped-Ag2S quantum dots (QDs) clusters were synthesized in aqueous phase via biomimetic route. The final products were characterized by UV-vis absorption, photoluminescence (PL) spectra, X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM). Our results revealed that RNase A-Ag2S QDs clusters owned a good photoluminescence property. In addition, RNase A-Ag2S QDs exhibited a good biocompatibility by tetrazolium based colorimetric assay (MTT test). In this work, RNase A not only serves as a stabilizer agent in the formation of Ag2S QDs to avoid aggregation, but also is a biomolecule to modify the surface of Ag2S QDs to decrease toxicity. These prepared RNase A-Ag2S QDs clusters have great potential applications in molecular imaging in living cells and tissues. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：224 / 227

页数：4

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