Multiple myeloma preparative regimens for high-dose therapy and autologous transplantation: what's new?

被引：0
|
作者：
Aljitawi, Omar S. [1 ]
McGuirk, Joseph P. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Blood & Marrow Transplant Program, Kansas City, KS 66103 USA
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2012年 / 1卷 / 01期
关键词：
autologous; chemotherapy; multiple myeloma; preparative regimen; review; transplant; STEM-CELL TRANSPLANTATION; CONDITIONING REGIMEN; PHASE-II; RANDOMIZED-TRIAL; ALLOGENEIC TRANSPLANTATION; INTERGROUPE FRANCOPHONE; STANDARD CHEMOTHERAPY; 200 MG/M(2); MELPHALAN; CYCLOPHOSPHAMIDE;
D O I：
10.2217/CER.11.11
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
High-dose chemotherapy and autologous stem cell transplantation remains a standard procedure in relatively young and selected older patients with multiple myeloma. High-dose melphalan has remained the chemotherapeutic agent of choice based on earlier prospective randomized trials. Despite investigations involving different combinations of chemotherapeutics, radiation and novel agents with and without melphalan, none of these alternative preparative regimens have demonstrated superiority to high-dose melphalan used as a single agent in multiple published studies. In this article, we review the published literature regarding preparative regimens used in patients with multiple myeloma undergoing autologous stem cell transplantation.
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页码：57 / 70
页数：14
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