HOX genes, reviewing the molecular bridges between developmental anomalies and cancer

被引：0

作者：

Mambet, Cristina ^{[1
]}

Necula, Laura G. ^{[1
]}

Neagu, Ana I. ^{[1
]}

Aldea, Ioana M. ^{[1
]}

Matei, Lilia ^{[1
]}

Dragu, Denisa ^{[1
]}

Livadariu, Mirela ^{[2
]}

Economescu, Mihaelachivu ^{[1
]}

Bleotu, Coralia ^{[1
]}

Ion, Daniela ^{[3
]}

Diaconu, Carmen C. ^{[1
]}

机构：

[1] Stefan S Nicolau Inst Virol, Bucharest, Romania

[2] CBC Labs SA, Cluj Napoca, Romania

[3] Carol Davila Univ Med & Pharm, Prof Dr MateiBals Natl Inst Infect Dis, European HIV AIDS Acad, Bucharest, Romania

来源：

ROMANIAN BIOTECHNOLOGICAL LETTERS | 2015年 / 20卷 / 03期

关键词：

Hox genes; ASXL; developmental anomalies; cancer; cell therapy strategies; ACUTE MYELOID-LEUKEMIA; MYELODYSPLASTIC SYNDROMES; CONGENITAL ABSENCE; ASXL1; MUTATIONS; EXPRESSION; OVEREXPRESSION; HEMATOPOIESIS; MALFORMATIONS; EXPANSION; UTERUS;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hox genes are critical regulators of embryonic development, being involved in formation of the skeleton and limbs, craniofacial morphogenesis, and in development of the central nervous system, gastrointestinal and urogenital tracts. Furthermore, in adults, Hox genes play an important role in cell renewal and tissue regeneration processes such as hematopoiesis, angiogenesis, spermatogenesis and endometrial remodeling. Aberrant expression of Hox genes have been described indevelopmental abnormalities and solid tumorsas well as inhematologic malignancies and this review aims to explore the connection between these two areas of pathology.

引用

页码：10504 / 10511

页数：8

共 46 条

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