New anticoagulants for treatment of venous thromboembolism

被引：24

作者：

Franchini, Massimo ^{[1
]}

Mannucci, Pier Mannuccio ^{[2
]}

机构：

[1] Carlo Poma Hosp, Dept Transfus Med & Hematol, Mantua, Italy

[2] IRCCS Ca Granda Fdn Maggiore Hosp, Sci Direct, Milan, Italy

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2012年 / 23卷 / 08期

关键词：

Dabigatran; Rivaroxaban; Apixaban; Edoxaban; Deep vein thrombosis; Pulmonary embolism; EXTENDED MAINTENANCE THERAPY; ORAL RIVAROXABAN; DABIGATRAN; WARFARIN;

D O I：

10.1016/j.ejim.2012.10.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Venous thromboembolism (VTE) is a major cause of morbidity and mortality and anticoagulation is the cornerstone of treatment. Although effective, traditional anticoagulants (i.e., heparins and vitamin K antagonists) have significant limitations and there are several unmet needs. Therefore, new drugs have been developed, including direct factor Xa inhibitors (e. g., rivaroxaban, apixaban and edoxaban) and thrombin inhibitors (e. g., dabigatran etexilate). The characteristics of these agents and the main results of published clinical studies dealing with VTE treatment are critically summarized in this article. (C) 2012 European Federation of Internal Medicine. Published by Elsevier B. V. All rights reserved.

引用

页码：692 / 695

页数：4

共 27 条

[21]

Schulman S, 2011, J THROMB HAEMOST, V9, P22

[22]

Schulman S., 2011, ASH ANN M

[23] Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism. [J].

Schulman, Sam ;

Kearon, Clive ;

Kakkar, Ajay K. ;

Mismetti, Patrick ;

Schellong, Sebastian ;

Eriksson, Henry ;

Baanstra, David ;

Schnee, Janet ;

Goldhaber, Samuel Z. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (24) :2342-2352

[24] Trends in the incidence of deep vein thrombosis and pulmonary embolism -: A 25-year population-based study [J].

Silverstein, MD ;

Heit, JA ;

Mohr, DN ;

Petterson, TM ;

O'Fallon, WM ;

Melton, LJ .

ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (06) :585-593

[25] Influence of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate An Open-Label, Parallel-Group, Single-Centre Study [J].

Stangier, Joachim ;

Rathgen, Karin ;

Stahle, Hildegard ;

Mazur, Dago .

CLINICAL PHARMACOKINETICS, 2010, 49 (04) :259-268

[26] The epidemiology of venous thromboembolism [J].

White, RH .

CIRCULATION, 2003, 107 :I4-I8

[27] Venous Thromboembolism Risk Factors for Recurrence [J].

Zhu, Tienan ;

Martinez, Isabelle ;

Emmerich, Joseph .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (03) :298-310

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