Electro-Oxidation Mechanism of Meloxicam and Electrochemical Sensing Platform Based on Graphene Nanoparticles for its Sensing Pharmaceutical Sample

Background: Electrochemical oxidation mechanism and electrochemical determination of meloxicam (M), an anti-artrithtis agent, were investigated by cyclic voltammetry and square wave adsorptive stripping voltammetry, respectively. Objective: In this study, we aimed to investigate the electrochemical redox mechanism and develop a nano-sensor for sensitive, fast and selective analysis of meloxicam. Methods: In this study, the three-electrode system was used for all voltammetric measurements. Firstly, the graphene content of GR/CPE sensor was changed in the range of 1.67% to 6.68%. Then, the surface characterization of modified electrode was carried out by using Electrochemical Empedance Spectro-scopy and Surface Electron Microscopy methods. Some analytical parameters, such as pH, accumulation potential and accumulation time were optimized and by using optimum parameters, calibration study was established. Results: The GR/CPE with a graphene content of 3.33 % was found to have the best voltammetric signal with a linear working range of 0.1-10 mu M. The sensitivity of the quantitative voltammetric method towards M is fairly good with an LOQ of 0.0088 mu mol/L and LOD of 0.0026 mu mol/L. Conclusion: The optimum pH, accumulation time and accumulation potential were found to be 2.0, 150s and 0.0 V, respectively. The height of the voltammetric signal obtained with the GR/CPE electrode was stable with a 4.0 % deviation for a period of not shorter than 1 months.