Spirometric Reference Values for Advanced Age from a South German Population

被引:12
作者
Karrasch, Stefan [1 ]
Flexeder, Claudia [5 ]
Behr, Juergen [8 ]
Holle, Rolf [7 ]
Huber, Rudolf M. [2 ]
Joerres, Rudolf A. [1 ]
Nowak, Dennis [1 ]
Peters, Annette [6 ]
Wichmann, H-Erich [3 ,4 ,5 ]
Heinrich, Joachim [5 ]
Schulz, Holger [5 ]
机构
[1] Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, DE-80336 Munich, Germany
[2] Univ Munich, Div Resp Med, Dept Med, DE-80336 Munich, Germany
[3] Univ Munich, Inst Med Data Management Biometr & Epidemiol, DE-80336 Munich, Germany
[4] Univ Munich, Klinikum Grosshadern, DE-80336 Munich, Germany
[5] Helmholtz Zentrum Munchen, Inst Epidemiol 1, Munich, Germany
[6] Helmholtz Zentrum Munchen, Inst Epidemiol 2, Munich, Germany
[7] Helmholtz Zentrum Munchen, Inst Hlth Econ & Hlth Care Management, Munich, Germany
[8] Ruhr Univ Bochum, Dept Internal Med 3, Univ Hosp Bergmannsheil, Bochum, Germany
关键词
Spirometry; Prediction equations; Ageing; Elderly; Quantile regression; LUNG-FUNCTION; REFERENCE EQUATIONS; QUANTILE REGRESSION; REFERENCE RANGES; MODELS; PREDICTION; OBSTRUCTION; CHILDHOOD; SAMPLE; ADULTS;
D O I
10.1159/000338780
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: The diagnostic use of lung function using spirometry depends on the validity of reference equations. A multitude of spirometric prediction values have been published, but in most of these studies older age groups are underrepresented. Objectives: The aim of the present study was to establish new spirometric reference values for advanced age and to compare these to recent prediction equations from population-based studies. Methods: In the present study spirometry was performed in a population-based sample from the KORA-F4 and KORA-Age cohorts (2006-2009, Augsburg, Germany) comprising 592 never-smoking subjects aged 42-89 years and with no history of respiratory disease. Using quantile regression analysis, equations for the median and lower limit of normal were derived for indices characterizing the expiratory flow-volume curve: forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF), and forced expiratory flow rates at 25, 50 and 75% of exhaled FVC (FEF25, FEF50 and FEF75). Results: FEV1 and FVC were slightly higher, and PEF was lower compared to recently published equations. Importantly, forced expiratory flow rates at middle and low lung volume, as putative indicators of small airway disease, were in good agreement with recent data, especially for older age. Conclusion: Our study provides up-to-date reference equations for all major indices of flow-volume curves in middle and advanced age in a South German population. The small deviations from published equations indicate that there might be some regional differences of lung function within the Caucasian population of advanced age in Europe. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码:210 / 219
页数:10
相关论文
共 33 条
  • [1] Alternative regression models to assess increase in childhood BMI
    Beyerlein, Andreas
    Fahrmeir, Ludwig
    Mansmann, Ulrich
    Toschke, Andre M.
    [J]. BMC MEDICAL RESEARCH METHODOLOGY, 2008, 8 (1)
  • [2] STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
    BLAND, JM
    ALTMAN, DG
    [J]. LANCET, 1986, 1 (8476) : 307 - 310
  • [3] Percentiles of Inspiratory Capacity in Healthy Nonsmokers: A Pilot Study
    Bottai, Matteo
    Pistelli, Francesco
    Di Pede, Francesco
    Baldacci, Sandra
    Simoni, Marzia
    Maio, Sara
    Carrozzi, Laura
    Viegi, Giovanni
    [J]. RESPIRATION, 2011, 82 (03) : 254 - 262
  • [4] Age- and size-related reference ranges: A case study of spirometry through childhood and adulthood
    Cole, T. J.
    Stanojevic, S.
    Stocks, J.
    Coates, A. L.
    Hankinson, J. L.
    Wade, A. M.
    [J]. STATISTICS IN MEDICINE, 2009, 28 (05) : 880 - 898
  • [5] LINEAR AND PROPORTIONAL REGRESSION MODELS IN PREDICTION OF VENTILATORY FUNCTION
    COLE, TJ
    [J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, 1975, 138 : 297 - 338
  • [6] Prediction equations for normal and low lung function from the Health Survey for England
    Falaschetti, E
    Laiho, J
    Primatesta, P
    Purdon, S
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2004, 23 (03) : 456 - 463
  • [7] Fenske N, 2008, 038 U MUN DEP STAT
  • [8] Overdiagnosing Subjects With COPD Using the 0.7 Fixed Ratio: Correlation With a Poor Health-Related Quality of Life
    Garcia-Rio, Francisco
    Soriano, Joan B.
    Miravitlles, Marc
    Munoz, Luis
    Duran-Tauleria, Enric
    Sanchez, Guadalupe
    Sobradillo, Victor
    Ancochea, Julio
    [J]. CHEST, 2011, 139 (05) : 1072 - 1080
  • [9] KORA -: A research platform for population based health research
    Holle, R
    Happich, M
    Löwel, H
    Wichmann, HE
    [J]. GESUNDHEITSWESEN, 2005, 67 : S19 - S25
  • [10] Lung function reference values in different German populations
    Koch, Beate
    Schaeper, Christoph
    Ewert, Ralf
    Voelzke, Henry
    Obst, Anne
    Friedrich, Nele
    Felix, Stephan B.
    Vogelmeier, Claus F.
    Schnabel, Eva
    Karrasch, Stefan
    Wichmann, H. E.
    Schaefer, Torsten
    Schulz, Holger
    Heinrich, Joachim
    Glaeser, Sven
    [J]. RESPIRATORY MEDICINE, 2011, 105 (03) : 352 - 362