Antioxidant and antihyperlipidemic activities of polysaccharides from sea cucumber Apostichopus japonicus

被引：209

作者：

Liu, Xin ^{[1
]}

Sun, Zhenliang ^{[3
]}

Zhang, Miansong ^{[2
]}

Meng, Xiumei ^{[1
]}

Xia, Xuekui ^{[2
]}

Yuan, Wenpeng ^{[1
]}

Xue, Feng ^{[3
]}

Liu, Changheng ^{[1
]}

机构：

[1] Shandong Acad Sci, Inst Biol, Key Lab Biosensors Shandong Prov, Jinan 250014, Peoples R China

[2] Shandong Acad Sci, Ctr Biotechnol, Key Lab Appl Microbiol Shandong Prov, Jinan 250014, Peoples R China

[3] Shanghai 6 Peoples Hosp, Branch Hosp Fengxian, Shanghai 201499, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Apostichopus japonicus; Polysaccharide; Antioxidant activity; Antihyperlipidemic activity; OXIDATIVE STRESS;

D O I：

10.1016/j.carbpol.2012.07.047

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polysaccharides (AJP) were prepared from Apostichopus japonicus by protease hydrolysis method. Antioxidant activity in vitro and antihyperlipidemic activity in vivo was investigated. Chemical composition analysis indicated that AJP was mainly composed of glucosamine, galactosamine, glucuronic acid, mannose, glucose, galactose and fucose, with an average molecular weight of about 36.2 kDa. The antioxidant capacities of AJP were, respectively, evaluated by the assays of scavenging DPPH, hydroxyl and superoxide radicals, and reducing power in vitro. It showed potent free radical scavenging activities and reducing power. Serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL-C) decreased significantly and high-density lipoprotein cholesterol (HDL-C) increased significantly after treatment of hyperlipidemic Wistar rats with AJP. These results suggest that AJP may prove to be a potential candidate of the natural antioxidants as a therapeutic agent for hyperlipidemia. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：1664 / 1670

页数：7

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