Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory

被引:22
作者
Boumghar, Katia [1 ]
Couret-Fauvel, Thomas [1 ]
Garcia, Mikael [2 ]
Armengaud, Catherine [1 ]
机构
[1] Univ Toulouse 3, Ctr Rech Cognit Anim, CNRS, UMR 5169, F-31062 Toulouse 4, France
[2] Univ Bordeaux 2, F-33076 Bordeaux, France
关键词
Honeybee; Mushroom bodies; Olfactory conditioning; GABA; Glutamate; Picrotoxin; LONG-TERM-MEMORY; HONEYBEES APIS-MELLIFERA; MUSHROOM BODIES; RETROGRADE-AMNESIA; ANTENNAL LOBES; PROTEIN-KINASE; RECEPTOR; PICROTOXIN; BRAIN; BEE;
D O I
10.1016/j.pbb.2012.08.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning using a single-trial olfactory conditioning paradigm. The GABAergic antagonist picrotoxin (PTX) or the GluCI antagonist L-trans-pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) was injected alone or in combination into the a-lobes of MBs. PTX impaired early long-term olfactory memory when injected before conditioning or before testing. L-trans-PDC alone induced no significant effect on learning and memory but induced a less specific response to the conditioned odor. When injected before PTX, L-trans-PDC was able to modulate PTX effects. These results emphasize the role of MB GABA-gated chloride channels in consolidation processes and strongly support that GluCls are involved in the perception of the conditioned stimulus. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:69 / 75
页数:7
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