Rapid microwave assisted synthesis and characterization of nanosized silver-doped hydroxyapatite with antibacterial properties

被引：71
|
作者：
Iqbal, Nida [1 ]
Kadir, Mohammed Rafiq Abdul [1 ]
Malek, Nik Ahmad Nizam Nik [2 ,3 ]
Mahmood, Nasrul Humaimi [1 ]
Murali, Malliga Raman [4 ]
Kamarul, Tunku [4 ]
机构：
[1] Univ Teknol Malaysia, Med Implant Technol Grp MEDITEG, Fac Biomed Engn & Hlth Sci, Skudai 81310, Johor Darul Tak, Malaysia
[2] Univ Teknol Malaysia, Fac Biosci & Bioengn, Skudai 81310, Johor Darul Tak, Malaysia
[3] Univ Teknol Malaysia, Inst Ibnu Sina Fundamental Sci Studies, Skudai 81310, Johor Darul Tak, Malaysia
[4] Univ Malaya, Tissue Engn Grp, Dept Orthopaed Surg, NOCERAL,Fac Med, Kuala Lumpur 50603, Malaysia
来源：
MATERIALS LETTERS | 2012年 / 89卷
关键词：
Biomaterial; Hydroxyapatite; Nano particles; Microwave irradiation; Antibacterial activity; SUBSTITUTED HYDROXYAPATITE;
D O I：
10.1016/j.matlet.2012.08.057
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Synthesis of nanosized particles of silver-doped hydroxyapatite (Ag-HA) as an antibacterial agent is of potential importance in managing infections associated with surgical implants. However, the process of synthesizing this agent is time consuming and inefficient. To overcome this problem, a rapid method for synthesizing nano-sized Ag-doped hydroxyapatite (Ag-HA) [Ca10-xAgx(PO4)(6)(OH)(2)] (x=0.03-0.5) using microwave irradiation for 10 min at 800 W is proposed. The materials were characterized using XRD, FTIR, FESEM and EDX. Antibacterial behavior of the Ag-HA samples were evaluated using disc diffusion technique and results demonstrated good activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：118 / 122
页数：5
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