Abnormalities of coagulation, platelet function, and fibrinolysis associated with syndromes of insulin resistance

被引：48
作者：
Schneider, DJ [1 ]
机构：
[1] Univ Vermont, Colchester, VT 05446 USA
来源：
CORONARY ARTERY DISEASE | 2005年 / 16卷 / 08期
关键词：
coagulation; fibrinolysis; insulin resistance; plasminogen activator inhibitor type 1; platelets;
D O I：
10.1097/00019501-200512000-00003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin resistance that accompanies obesity, hypertension, polycystic ovary syndrome, and the early phases of type 2 diabetes is characterized by a prothrombotic state. The prothrombotic state is a reflection of the direct effects of hyperinsulinemia and associated metabolic abnormalities (postprandial hyperglycemia, increased free fatty acids, and hypertriglyceridemia) on platelets, coagulation, and fibrinolysis. Therapies that improve insulin sensitivity and thereby decrease insulin resistance, hyperinsulinemia, and metabolic abnormalities decrease the prothrombotic state.
引用
收藏
页码：473 / 476
页数：4
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