Abnormalities of coagulation, platelet function, and fibrinolysis associated with syndromes of insulin resistance

被引：48
作者：
Schneider, DJ [1 ]
机构：
[1] Univ Vermont, Colchester, VT 05446 USA
来源：
CORONARY ARTERY DISEASE | 2005年 / 16卷 / 08期
关键词：
coagulation; fibrinolysis; insulin resistance; plasminogen activator inhibitor type 1; platelets;
D O I：
10.1097/00019501-200512000-00003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin resistance that accompanies obesity, hypertension, polycystic ovary syndrome, and the early phases of type 2 diabetes is characterized by a prothrombotic state. The prothrombotic state is a reflection of the direct effects of hyperinsulinemia and associated metabolic abnormalities (postprandial hyperglycemia, increased free fatty acids, and hypertriglyceridemia) on platelets, coagulation, and fibrinolysis. Therapies that improve insulin sensitivity and thereby decrease insulin resistance, hyperinsulinemia, and metabolic abnormalities decrease the prothrombotic state.
引用
收藏
页码：473 / 476
页数：4
相关论文
共 50 条
  • [1] Human bone marrow megakaryocytes and platelets express PPARγ, and PPARγ agonists blunt platelet release of CD40 ligand and thromboxanes
    Akbiyik, F
    Ray, DM
    Gettings, KF
    Blumberg, N
    Francis, CW
    Phipps, RP
    [J]. BLOOD, 2004, 104 (05) : 1361 - 1368
  • [2] Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
    Alessi, MC
    Bastelica, D
    Mavri, A
    Morange, P
    Berthet, B
    Grino, M
    Juhan-Vague, I
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (07) : 1262 - 1268
  • [3] Production of plasminogen activator inhibitor 1 by human adipose tissue - Possible link between visceral fat accumulation and vascular disease
    Alessi, MC
    Peiretti, F
    Morange, P
    Henry, M
    Nalbone, G
    JuhanVague, I
    [J]. DIABETES, 1997, 46 (05) : 860 - 867
  • [4] IMMUNOLOGICAL IDENTIFICATION AND COMPARISON OF PLASMINOGEN-ACTIVATOR FORMS IN CULTURED NORMAL HUMAN-ENDOTHELIAL CELLS AND SMOOTH-MUSCLE CELLS
    BOOYSE, FM
    SCHEINBUKS, J
    RADEK, J
    OSIKOWICZ, G
    FEDER, S
    QUARFOOT, AJ
    [J]. THROMBOSIS RESEARCH, 1981, 24 (5-6) : 495 - 504
  • [5] Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects
    Calles-Escandon, J
    Mirza, SA
    Sobel, BE
    Schneider, DJ
    [J]. DIABETES, 1998, 47 (02) : 290 - 293
  • [6] Local insulin infusion stimulates expression of plasminogen activator inhibitor-1 and tissue-type plasminogen activator in normal subjects
    Carmassi, F
    Morale, M
    Ferrini, L
    Dell'Omo, G
    Ferdeghini, M
    Pedrinelli, R
    De Negri, F
    [J]. AMERICAN JOURNAL OF MEDICINE, 1999, 107 (04) : 344 - 350
  • [7] Chen Y, 2002, NUTR METAB CARDIOVAS, V12, P325
  • [8] Identification and localization of a fatty acid response region in the human plasminogen activator inhibitor-1 gene
    Chen, YB
    Billadello, JJ
    Schneider, DJ
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (12) : 2696 - 2701
  • [9] THROMBOXANE BIOSYNTHESIS AND PLATELET-FUNCTION IN TYPE-II DIABETES-MELLITUS
    DAVI, G
    CATALANO, I
    AVERNA, M
    NOTARBARTOLO, A
    STRANO, A
    CIABATTONI, G
    PATRONO, C
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (25) : 1769 - 1774
  • [10] C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells
    Devaraj, S
    Xu, DY
    Jialal, I
    [J]. CIRCULATION, 2003, 107 (03) : 398 - 404
12345