The number of p16INK4a positive cells in human skin reflects biological age

被引：213
作者：
Waaijer, Mariette E. C. [1 ]
Parish, William E. [2 ]
Strongitharm, Barbara H. [2 ]
van Heemst, Diana [1 ,3 ]
Slagboom, Pieternella E. [4 ]
de Craen, Anton J. M. [1 ,3 ]
Sedivy, John M. [5 ]
Westendorp, Rudi G. J. [1 ,3 ]
Gunn, David A. [2 ]
Maier, Andrea B. [1 ,3 ]
机构：
[1] Leiden Univ, Dept Gerontol & Geriatr, Med Ctr, NL-2300 RC Leiden, Netherlands
[2] Colworth Sci Pk, Unilever Discover, Sharnbrook, Beds, England
[3] Leiden Univ, Netherlands Consortium Hlth Aging, Med Ctr, NL-2300 RC Leiden, Netherlands
[4] Leiden Univ, Dept Mol Epidemiol, Med Ctr, NL-2300 RC Leiden, Netherlands
[5] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02903 USA
来源：
AGING CELL | 2012年 / 11卷 / 04期
关键词：
p16INK4a; biological age; familial longevity; cellular senescence; CYCLE INHIBITOR P16(INK4A); CELLULAR SENESCENCE; LEIDEN LONGEVITY; IN-VIVO; EXPRESSION; BIOMARKER; DAMAGE;
D O I：
10.1111/j.1474-9726.2012.00837.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.
引用
收藏
页码：722 / 725
页数：4
相关论文
共 24 条
[1]   Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].
Baker, Darren J. ;
Wijshake, Tobias ;
Tchkonia, Tamar ;
LeBrasseur, Nathan K. ;
Childs, Bennett G. ;
van de Sluis, Bart ;
Kirkland, James L. ;
van Deursen, Jan M. .
NATURE, 2011, 479 (7372) :232-U112
[2]   Cellular senescence: when bad things happen to good cells [J].
Campisi, Judith ;
di Fagagna, Fabrizio d'Adda .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (09) :729-740
[3]   Stress-induced responses of human skin fibroblasts in vitro reflect human longevity [J].
Dekker, Pim ;
Maier, Andrea B. ;
van Heemst, Diana ;
de Koning-Treurniet, Corine ;
Blom, Joke ;
Dirks, Roeland W. ;
Tanke, Hans J. ;
Westendorp, Rudi G. J. .
AGING CELL, 2009, 8 (05) :595-603
[4]   A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO [J].
DIMRI, GP ;
LEE, XH ;
BASILE, G ;
ACOSTA, M ;
SCOTT, C ;
ROSKELLEY, C ;
MEDRANO, EE ;
LINSKENS, M ;
RUBELJ, I ;
PEREIRASMITH, O ;
PEACOCKE, M ;
CAMPISI, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) :9363-9367
[5]   Does oxidative damage to DNA increase with age? [J].
Hamilton, ML ;
Van Remmen, H ;
Drake, JA ;
Yang, H ;
Guo, ZM ;
Kewitt, K ;
Walter, CA ;
Richardson, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10469-10474
[6]   Cellular senescence in aging primates [J].
Herbig, U ;
Ferreira, M ;
Condel, L ;
Carey, D ;
Sedivy, JM .
SCIENCE, 2006, 311 (5765) :1257-1257
[7]   Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a [J].
Janzen, Viktor ;
Forkert, Randolf ;
Fleming, Heather E. ;
Saito, Yoriko ;
Waring, Michael T. ;
Dombkowski, David M. ;
Cheng, Tao ;
DePinho, Ronald A. ;
Sharpless, Norman E. ;
Scadden, David T. .
NATURE, 2006, 443 (7110) :421-426
[8]   Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation [J].
Koppelstaetter, Christian ;
Schratzberger, Gabriele ;
Perco, Paul ;
Hofer, Johannes ;
Mark, Walter ;
Oellinger, Robert ;
Oberbauer, Rainer ;
Schwarz, Christoph ;
Mitterbauer, Christa ;
Kainz, Alexander ;
Karkoszka, Henryk ;
Wiecek, Andrzej ;
Mayer, Bernd ;
Mayer, Gert .
AGING CELL, 2008, 7 (04) :491-497
[9]   Ink4a/Arf expression is a biomarker of aging [J].
Krishnamurthty, J ;
Torrice, C ;
Ramsey, MR ;
Kovalev, GI ;
Al-Regaiey, K ;
Su, LS ;
Sharpless, NE .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (09) :1299-1307
[10]   p16INK4a induces an age-dependent decline in islet regenerative potential [J].
Krishnamurthy, Janakiraman ;
Ramsey, Matthew R. ;
Ligon, Keith L. ;
Torrice, Chad ;
Koh, Angela ;
Bonner-Weir, Susan ;
Sharpless, Norman E. .
NATURE, 2006, 443 (7110) :453-457
123