Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal

被引:119
作者
Dampney, Roger A. L. [1 ,2 ]
机构
[1] Univ Sydney, Sch Med Sci Physiol, Sydney, NSW 2006, Australia
[2] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
defensive behavior; sympathetic activity; respiratory activity; hypothalamus; mid-brain; sympathetic premotor nuclei; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; ADIPOSE-TISSUE THERMOGENESIS; SYMPATHETIC-NERVE ACTIVITY; C-FOS EXPRESSION; DORSOLATERAL PERIAQUEDUCTAL GRAY; ROSTRAL VENTROLATERAL MEDULLA; MEDIAL PREFRONTAL CORTEX; OREXIN KNOCKOUT MICE; DORSOMEDIAL HYPOTHALAMUS; MENTAL STRESS;
D O I
10.1152/ajpregu.00051.2015
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Actual or potentially threatening stimuli in the external environment (i.e., psychological stressors) trigger highly coordinated defensive behavioral responses that are accompanied by appropriate autonomic and respiratory changes. As discussed in this review, several brain regions and pathways have major roles in subserving the cardiovascular and respiratory responses to threatening stimuli, which may vary from relatively mild acute arousing stimuli to more prolonged life-threatening stimuli. One key region is the dorsomedial hypothalamus, which receives inputs from the cortex, amygdala, and other fore-brain regions and which is critical for generating autonomic, respiratory, and neuroendocrine responses to psychological stressors. Recent studies suggest that the dorsomedial hypothalamus also receives an input from the dorsolateral column in the midbrain periaqueductal gray, which is another key region involved in the integration of stress-evoked cardiorespiratory responses. In addition, it has recently been shown that neurons in the midbrain colliculi can generate highly synchronized autonomic, respiratory, and somatomotor responses to visual, auditory, and somatosensory inputs. These collicular neurons may be part of a subcortical defense system that also includes the basal ganglia and which is well adapted to responding to threats that require an immediate stereotyped response that does not involve the cortex. The basal ganglia/colliculi system is phylogenetically ancient. In contrast, the defense system that includes the dorsomedial hypothalamus and cortex evolved at a later time, and appears to be better adapted to generating appropriate responses to more sustained threatening stimuli that involve cognitive appraisal.
引用
收藏
页码:R429 / R443
页数:15
相关论文
共 168 条
[1]  
ABDEEN OA, 1995, J PHARMACOL EXP THER, V272, P282
[2]   How many types of cholinergic sympathetic neuron are there in the rat stellate ganglion? [J].
Anderson, C. R. ;
Bergner, A. ;
Murphy, S. M. .
NEUROSCIENCE, 2006, 140 (02) :567-576
[3]   A COMPARISON OF HYPOTENSIVE AND NONHYPOTENSIVE HEMORRHAGE ON FOS EXPRESSION IN SPINALLY PROJECTING NEURONS OF THE PARAVENTRICULAR NUCLEUS AND ROSTRAL VENTROLATERAL MEDULLA [J].
BADOER, E ;
MCKINLEY, MJ ;
OLDFIELD, BJ ;
MCALLEN, RM .
BRAIN RESEARCH, 1993, 610 (02) :216-223
[4]   Central circuits mediating patterned autonomic activity during active vs. passive emotional coping [J].
Bandler, R ;
Keay, KA ;
Floyd, N ;
Price, J .
BRAIN RESEARCH BULLETIN, 2000, 53 (01) :95-104
[5]   COLUMNAR ORGANIZATION IN THE MIDBRAIN PERIAQUEDUCTAL GRAY - MODULES FOR EMOTIONAL EXPRESSION [J].
BANDLER, R ;
SHIPLEY, MT .
TRENDS IN NEUROSCIENCES, 1994, 17 (09) :379-389
[6]  
BARCROFT H, 1960, CLIN SCI, V19, P577
[7]   A review of central 5-HT receptors and their function [J].
Barnes, NM ;
Sharp, T .
NEUROPHARMACOLOGY, 1999, 38 (08) :1083-1152
[8]   Autonomic components of the cardiovascular responses to an acoustic startle stimulus in rats [J].
Baudrie, V ;
Tulen, JHM ;
Blanc, J ;
Elghozi, JL .
JOURNAL OF AUTONOMIC PHARMACOLOGY, 1997, 17 (05) :303-309
[9]   Paraventricular nucleus, stress response, and cardiovascular disease [J].
Benarroch, EE .
CLINICAL AUTONOMIC RESEARCH, 2005, 15 (04) :254-263
[10]  
BENZINGER H, 1983, EXP BRAIN RES, V50, P1