T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols

被引：37

作者：

Kumar, Kothanahally S. Sharath ^{[1
]}

Swaroop, Toreshettahally R. ^{[1
]}

Harsha, Kachigere B. ^{[1
]}

Narasimhamurthy, Kereyagalahally H. ^{[1
]}

Rangappa, Kanchugarakoppal S. ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 42期

关键词：

Propylphosphonic anhydride (T3P (R)); Cascade; 4-Thiazolidinones; Thioglycolic acid (or mercaptoacetic acid);

D O I：

10.1016/j.tetlet.2012.08.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Propylphosphonic anhydride (T3P (R))-DMSO mediated oxidation of alcohols to carbonyl compounds and their subsequent cyclization with aryl/hetero aryl amines and thioglycolic acid to afford 4-thiazolidinones has been reported. Synthesis of 4-thiazolidinones directly from alcohols has been carried out for the first time. Mild reaction conditions, wide functional group tolerance, ease of work-up, and good yields are the noteworthy features of this protocol. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5619 / 5623

页数：5

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