Towards tailored vaccine delivery: Needs, challenges and perspectives

被引：80

作者：

Amorij, Jean-Pierre ^{[2
]}

Kersten, Gideon F. A. ^{[2
]}

Saluja, Vinay ^{[2
]}

Tonnis, Wouter F. ^{[3
]}

Hinrichs, Wouter L. J. ^{[3
]}

Slutter, Bram ^{[4
]}

Bal, Suzanne M. ^{[5
]}

Bouwstra, Joke A. ^{[1
]}

Huckriede, Anke ^{[6
,7
]}

Jiskoot, Wim ^{[1
]}

机构：

[1] Leiden Univ, LACDR, Div Drug Delivery Technol, NL-2333 CC Leiden, Netherlands

[2] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[3] Univ Groningen RuG, Dept Pharmaceut Technol & Biopharm, Groningen, Netherlands

[4] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[5] Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Div Expt Immunol, NL-1105 AZ Amsterdam, Netherlands

[6] Univ Med Ctr Groningen, Mol Virol Sect, Dept Med Microbiol, NL-9713 AV Groningen, Netherlands

[7] Univ Groningen, Groningen, Netherlands

来源：

JOURNAL OF CONTROLLED RELEASE | 2012年 / 161卷 / 02期

关键词：

Adjuvant; Device; Formulation; Mucosal vaccination; Targeting; Transcutaneous vaccination; INFLUENZA SUBUNIT VACCINE; T-CELL RESPONSES; RESPIRATORY SYNCYTIAL VIRUS; TOLL-LIKE RECEPTORS; RECOMBINANT PROTEIN VACCINE; MEDIATED IMMUNE-RESPONSES; PHASE-I TRIAL; PLASMODIUM-FALCIPARUM; MALARIA VACCINE; DENDRITIC CELLS;

D O I：

10.1016/j.jconrel.2011.12.039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ideal vaccine is a simple and stable formulation which can be conveniently administered and provides life-long immunity against a given pathogen. The development of such a vaccine, which should trigger broad and strong B-cell and T-cell responses against antigens of the pathogen in question, is highly dependent on tailored vaccine delivery approaches. This review addresses vaccine delivery in its broadest scope. We discuss the needs and challenges in the area of vaccine delivery, including restrictions posed by specific target populations, potentials of dedicated stable formulations and devices, and the use of adjuvants. Moreover, we address the current status and perspectives of vaccine delivery via several routes of administration, including non-or minimally invasive routes. Finally we suggest possible directions for future vaccine delivery research and development. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：363 / 376

页数：14

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