Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus

被引：142

作者：

Mina, Rina ^{[2
]}

von Scheven, Emily ^{[1
]}

Ardoin, Stacy P. ^{[3
,4
]}

Eberhard, B. Anne ^{[5
]}

Punaro, Marilynn ^{[6
]}

Ilowite, Norman ^{[7
]}

Hsu, Joyce ^{[8
]}

Klein-Gitelman, Marisa ^{[9
]}

Moorthy, L. Nandini ^{[10
]}

Muscal, Eyal ^{[11
]}

Radhakrishna, Suhas M. ^{[12
]}

Wagner-Weiner, Linda ^{[13
]}

Adams, Matthew ^{[14
]}

Blier, Peter ^{[15
]}

Buckley, Lenore ^{[16
]}

Chalom, Elizabeth ^{[17
]}

Chedeville, Gaelle ^{[18
]}

Eichenfield, Andrew ^{[19
,20
]}

Fish, Natalya ^{[21
]}

Henrickson, Michael ^{[2
]}

Hersh, Aimee O. ^{[22
]}

Hollister, Roger ^{[23
]}

Jones, Olcay ^{[24
]}

Jung, Lawrence ^{[25
]}

Levy, Deborah ^{[26
]}

Lopez-Benitez, Jorge ^{[27
]}

McCurdy, Deborah ^{[28
]}

Miettunen, Paivi M. ^{[29
]}

Quintero-Del Rio, Ana I. ^{[30
]}

Rothman, Deborah ^{[31
]}

Rullo, Ornella ^{[28
]}

Ruth, Natasha ^{[32
]}

Schanberg, Laura E. ^{[33
]}

Silverman, Earl ^{[26
]}

Singer, Nora G. ^{[34
]}

Soep, Jennifer ^{[23
]}

Syed, Reema ^{[35
]}

Vogler, Larry B. ^{[36
]}

Yalcindag, Ali ^{[37
]}

Yildirim-Toruner, Cagri ^{[19
,20
]}

Wallace, Carol A. ^{[38
]}

Brunner, Hermine I. ^{[2
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

[2] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA

[3] Ohio State Univ, Columbus, OH 43210 USA

[4] Nationwide Childrens Hosp, Columbus, OH USA

[5] Steven & Alexandra Cohen Childrens Med Ctr New Yo, New York, NY USA

[6] Texas Scottish Rite Hosp Crippled Children, Dallas, TX USA

[7] Childrens Hosp Montefiore, Albert Einstein Coll Med, Bronx, NY USA

[8] Lucile Packard Childrens Hosp Stanford, Palo Alto, CA USA

[9] Childrens Mem Hosp, Chicago, IL 60614 USA

[10] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, New Brunswick, NJ USA

[11] Texas Childrens Hosp, Baylor Coll Med, Pediat Rheumatol Ctr, Houston, TX 77030 USA

[12] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[13] Univ Chicago, Comer Childrens Hosp, Chicago, IL 60637 USA

[14] Childrens Hosp Michigan, Detroit, MI 48201 USA

[15] Baystate Childrens Hosp, Springfield, MA USA

[16] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23284 USA

[17] St Barnabas Hosp, Livingston, NJ USA

[18] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Montreal, PQ H3H 1P3, Canada

[19] Morgan Stanley Childrens Hosp New York Presbyteri, New York, NY USA

[20] Columbia Univ, Med Ctr, New York, NY USA

[21] Penn State Hershey Childrens Hosp, Hershey, PA USA

[22] Univ Utah, Salt Lake City, UT USA

[23] Childrens Hosp Colorado, Aurora, CO USA

[24] Walter Reed Army Med Ctr, Washington, DC 20307 USA

[25] Childrens Natl Med Ctr, Washington, DC 20010 USA

[26] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[27] Tufts Med Ctr, Floating Hosp Children, Boston, MA USA

[28] Univ Calif Los Angeles, Mattel Childrens Hosp, Los Angeles, CA USA

[29] Univ Calgary, Calgary, AB, Canada

[30] Univ Cent Caribe, Bayamon, PR USA

[31] Shriners Hosp Children, Springfield, MA USA

[32] Med Univ S Carolina, Charleston, SC USA

[33] Duke Univ, Med Ctr, Durham, NC USA

[34] Case Western Reserve Univ, Sch Med, Metrohlth Med Ctr, Cleveland, OH USA

[35] St Louis Univ, St Louis, MO 63103 USA

[36] Emory Childrens Ctr, Atlanta, GA USA

[37] Hasbro Childrens Hosp, Providence, RI USA

[38] Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USA

来源：

ARTHRITIS CARE & RESEARCH | 2012年 / 64卷 / 03期

关键词：

QUALITY-OF-LIFE; MYCOPHENOLATE-MOFETIL TREATMENT; INTRAVENOUS CYCLOPHOSPHAMIDE; IDIOPATHIC ARTHRITIS; PRELIMINARY CRITERIA; CONTROLLED-TRIAL; RENAL-DISEASE; CHILDREN; CLASSIFICATION; GLOMERULONEPHRITIS;

D O I：

10.1002/acr.21558

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To formulate consensus treatment plans (CTPs) for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in juvenile systemic lupus erythematosus (SLE). Methods. A structured consensus formation process was employed by the members of the Childhood Arthritis and Rheumatology Research Alliance after considering the existing medical evidence and current treatment approaches. Results. After an initial Delphi survey ( response rate = 70%), a 2-day consensus conference, and 2 followup Delphi surveys ( response rates = 63-79%), consensus was achieved for a limited set of CTPs addressing the induction therapy of proliferative LN. These CTPs were developed for prototypical patients defined by eligibility characteristics, and included immunosuppressive therapy with either mycophenolic acid orally twice per day, or intravenous cyclophosphamide once per month at standardized dosages for 6 months. Additionally, the CTPs describe 3 options for standardized use of glucocorticoids, including a primarily oral, a mixed oral/intravenous, and a primarily intravenous regimen. There was consensus on measures of effectiveness and safety of the CTPs. The CTPs were well accepted by the pediatric rheumatology providers treating children with LN, and up to 300 children per year in North America are expected to be candidates for the treatment with the CTPs. Conclusion. CTPs for induction therapy of proliferative LN in juvenile SLE based on the available scientific evidence and pediatric rheumatology group experience have been developed. Consistent use of the CTPs may improve the prognosis of proliferative LN, and support the conduct of comparative effectiveness studies aimed at optimizing therapeutic strategies for proliferative LN in juvenile SLE.

引用

页码：375 / 383

页数：9

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