Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin

被引：196

作者：

van der Kraan, MIA ^{[1
]}

Groenink, J ^{[1
]}

Nazmi, K ^{[1
]}

Veerman, ECI ^{[1
]}

Bolscher, JGM ^{[1
]}

Amerongen, AVN ^{[1
]}

机构：

[1] Acad Ctr Dent Amsterdam, Dept Oral Biochem, NL-1081 BT Amsterdam, Netherlands

来源：

PEPTIDES | 2004年 / 25卷 / 02期

关键词：

antimicrobial peptide; lactoferrin; lactoferricin; lactoferrampin; C albicans; gram-positive bacterial; gram-negative bacteria;

D O I：

10.1016/j.peptides.2003.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antimicrobial activity of bovine lactoferrin is attributed to lactoferricin, situated in the N1-domain. Based on common features of antimicrobial peptides, a second putative antimicrobial domain was identified in the N1-domain of lactoferrin, designated lactoferrampin. This novel peptide exhibited candidacidal activity, which was substantially higher than the activity of lactoferrin. Furthermore, lactoferrampin was active against Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa, but not against the fermenting bacteria Actinomyces naeslundii, Porphyromonas gingivalis, Streptococcus mutans and Steptococcus sanguis. Notably, lactoferrampin is located in the N1-domain in close proximity to lactoferricin, which plays a crucial role in membrane-mediated activities of lactoferrin. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：177 / 183

页数：7

共 42 条

[1] ISOLATION OF 3 ANTIBACTERIAL PEPTIDES FROM PIG INTESTINE - GASTRIC-INHIBITORY POLYPEPTIDE(7-42), DIAZEPAM-BINDING INHIBITOR(32-86) AND A NOVEL FACTOR, PEPTIDE-3910 [J].

AGERBERTH, B ;

BOMAN, A ;

ANDERSSON, M ;

JORNVALL, H ;

MUTT, V ;

BOMAN, HG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 216 (02) :623-629

[2] Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts [J].

Andersen, JH ;

Osbakk, SA ;

Vorland, LH ;

Traavik, T ;

Gutteberg, TJ .

ANTIVIRAL RESEARCH, 2001, 51 (02) :141-149

[3] BACTERICIDAL EFFECT FOR HUMAN LACTOFERRIN [J].

ARNOLD, RR ;

COLE, MF ;

MCGHEE, JR .

SCIENCE, 1977, 197 (4300) :263-265

[4] ANTIBACTERIAL SPECTRUM OF LACTOFERRICIN-B, A POTENT BACTERICIDAL PEPTIDE DERIVED FROM THE N-TERMINAL REGION OF BOVINE LACTOFERRIN [J].

BELLAMY, W ;

TAKASE, M ;

WAKABAYASHI, H ;

KAWASE, K ;

TOMITA, M .

JOURNAL OF APPLIED BACTERIOLOGY, 1992, 73 (06) :472-479

[5]

BELLAMY W, 1993, MED MICROBIOL IMMUN, V182, P97, DOI 10.1007/BF00189377

[6] IDENTIFICATION OF THE BACTERICIDAL DOMAIN OF LACTOFERRIN [J].

BELLAMY, W ;

TAKASE, M ;

YAMAUCHI, K ;

WAKABAYASHI, H ;

KAWASE, K ;

TOMITA, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1121 (1-2) :130-136

[7] LACTOFERRIN - A MULTIFUNCTIONAL IMMUNOREGULATORY PROTEIN [J].

BROCK, J .

IMMUNOLOGY TODAY, 1995, 16 (09) :417-419

[8]

Chierici R, 2001, ADV NUTR RES, V10, P247

[9] Folding proteins into membranes [J].

Deber, CM ;

Goto, NK .

NATURE STRUCTURAL BIOLOGY, 1996, 3 (10) :815-818

[10] THE HELICAL HYDROPHOBIC MOMENT - A MEASURE OF THE AMPHIPHILICITY OF A HELIX [J].

EISENBERG, D ;

WEISS, RM ;

TERWILLIGER, TC .

NATURE, 1982, 299 (5881) :371-374

← 1 2 3 4 5 →