Calcineurin Inhibitors: Pharmacologic Mechanisms Impacting Both Insulin Resistance and Insulin Secretion Leading to Glucose Dysregulation and Diabetes Mellitus

被引：88
作者：
Chakkera, H. A. [1 ]
Kudva, Y. [2 ]
Kaplan, B. [1 ]
机构：
[1] Mayo Clin, Div Transplantat, Phoenix, AZ USA
[2] Mayo Clin, Div Endocrinol, Rochester, MN USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2017年 / 101卷 / 01期
关键词：
ENDOTHELIAL GROWTH-FACTOR; TYROSINE KINASE INHIBITORS; SINGLE NUCLEOTIDE POLYMORPHISMS; BREAST-CANCER; CARDIOVASCULAR-DISEASE; GENETIC POLYMORPHISMS; CARDIO-ONCOLOGY; POTENTIAL ROLE; SUNITINIB; CARDIOTOXICITY;
D O I：
10.1002/cpt.546
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Calcineurin inhibitors (CNIs), including tacrolimus and cyclosporine, are immune-modulating agents used in autoimmune disorders, glomerulonephritides, and after transplantation. CNIs are implicated as diabetogenic drugs but the mechanism is not clearly elucidated. Calcineurin is a cytosolic-phosphatase critical for T-lymphocyte activation. Calcineurin is widely distributed in different tissues responsible for glucose-regulation including pancreas, liver, skeletal muscle, adipocytes, brain, and gut. We describe the pharmacologic effects of CNIs in different tissues and impact on glucose regulation.
引用
收藏
页码：114 / 120
页数：7
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