The HER2 amplicon in breast cancer: Topoisomerase IIA and beyond

被引：47

作者：

Jacot, William ^{[1
,2
]}

Fiche, Maryse ^{[3
]}

Zaman, Khalil ^{[2
]}

Wolfer, Anita ^{[2
]}

Lamy, Pierre-Jean ^{[4
]}

机构：

[1] CRLC Val Aurelle Paul Lamarque, Serv Oncol Med, F-34298 Montpellier, France

[2] Univ Hosp CHUV, Breast Ctr CePO, CH-1011 Lausanne, Switzerland

[3] Univ Hosp CHUV, UIP, CH-7011 Lausanne, Switzerland

[4] CRLC Val Aurelle Paul Lamarque, Lab Biol Specials& & Oncogenet, F-34298 Montpellier, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2013年 / 1836卷 / 01期

关键词：

Breast cancer; HER2; Amplicon; IN-SITU HYBRIDIZATION; ALPHA GENE AMPLIFICATION; CIRCULATING TUMOR-CELLS; REVERSE TRANSCRIPTION-PCR; POLYMERASE CHAIN-REACTION; ACUTE REGULATORY PROTEIN; ESTROGEN-RECEPTOR-ALPHA; FACTOR BINDING-PROTEINS; ONCOTYPE DX TEST; GROWTH-FACTOR;

D O I：

10.1016/j.bbcan.2013.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HER2 gene amplification is observed in about 15% of breast cancers. The subgroup of HER2-positive breast cancers appears to be heterogeneous and presents complex patterns of gene amplification at the locus on chromosome 17q12-21. The molecular variations within the chromosome 17q amplicon and their clinical implications remain largely unknown. Besides the well-known TOP2A gene encoding Topoisomerase IIA, other genes might also be amplified and could play functional roles in breast cancer development and progression. This review will focus on the current knowledge concerning the HER2 amplicon heterogeneity, its clinical and biological impact and the pitfalls associated with the evaluation of gene amplifications at this locus, with particular attention to TOP2A and the link between TOP2A and anthracycline benefit. In addition it will discuss the clinical and biological implications of the amplification of ten other genes at this locus (MEDI, STARD3, GRB7, THRA, RARA, IGFPB4, CCR7, KRT20, KRT19 and GAST) in breast cancer. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：146 / 157

页数：12

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