Cationic Pd(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source

被引:36
作者
Shen, Kun [1 ]
Han, Xiuling [1 ]
Lu, Xiyan [1 ]
机构
[1] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
CATALYZED ASYMMETRIC HYDROGENATION; BOND-FORMING HYDROGENATION; C-C BONDS; CONJUGATE REDUCTION; CARBONYL ADDITION; COUPLING REACTION; ALPHA-KETOESTERS; ALLYLIC ALCOHOLS; OXIDATION LEVEL; VINYLATION;
D O I
10.1021/ol400531a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A cationic Pd(II)-catalyzed reductive cyclization of alkyne-tethered ketones or aldehydes using ethanol as hydrogen source under mild conditions was developed. The reaction is an environmentally benign synthetic method and proceeds efficiently to give useful N-heterocycles or carbocycles bearing an exocyclic double bond and a hydroxyl group in high yield.
引用
收藏
页码:1732 / 1735
页数:4
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