Cationic Pd(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source

被引：37

作者：

Shen, Kun ^{[1
]}

Han, Xiuling ^{[1
]}

Lu, Xiyan ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 07期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ASYMMETRIC HYDROGENATION; BOND-FORMING HYDROGENATION; C-C BONDS; CONJUGATE REDUCTION; CARBONYL ADDITION; COUPLING REACTION; ALPHA-KETOESTERS; ALLYLIC ALCOHOLS; OXIDATION LEVEL; VINYLATION;

D O I：

10.1021/ol400531a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cationic Pd(II)-catalyzed reductive cyclization of alkyne-tethered ketones or aldehydes using ethanol as hydrogen source under mild conditions was developed. The reaction is an environmentally benign synthetic method and proceeds efficiently to give useful N-heterocycles or carbocycles bearing an exocyclic double bond and a hydroxyl group in high yield.

引用

页码：1732 / 1735

页数：4

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