High serum C1q-adiponectin/total adiponectin ratio correlates with coronary artery disease in Japanese type 2 diabetics

被引：14

作者：

Hirata, Ayumu ^{[1
]}

Kishida, Ken ^{[1
]}

Nakatsuji, Hideaki ^{[1
]}

Kobayashi, Hironori ^{[2
]}

Funahashi, Tohru ^{[1
,3
]}

Shimomura, Iichiro ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan

[2] Otsuka Pharmaceut Co Ltd, Div Diagnost, Dept Res & Dev, Tokushima 77101, Japan

[3] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, Osaka, Japan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2013年 / 62卷 / 04期

关键词：

Adiponectin; C1q; C1q-binding adiponectin; Coronary artery disease; ADIPOSE-SPECIFIC PROTEIN; PLASMA-CONCENTRATIONS; ATHEROSCLEROSIS; COMPLEMENT; ASSOCIATION; DECREASE; MICE; C1Q;

D O I：

10.1016/j.metabol.2012.10.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Adiponectin, an adipocyte-derived protein, has potential antiatherogenic properties. Low levels of serum total-adiponectin (Total-APN) correlate with diabetes and coronary artery disease (CAD). Adiponectin and C1q form a protein complex in blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We investigated the correlation between C1q-APN and CAD in patients with type 2 diabetes mellitus (T2DM). Methods. The study subjects were 107 outpatients with T2DM who underwent evaluation for CAD. Blood C1q, Total-APN, high-molecular weight-adiponectin (HMW-APN) and C1q-APN were measured by enzyme-linked immunosorbent assays. Results. Serum levels of C1q-APN/Total-APN ratio were higher in patients diagnosed with CAD (10.47 +/- 0.59, mean +/- SEM, n=54) than those without CAD (8.88 +/- 0.60, n=53, p=0.0482). Age- and sex-adjusted logistic regression analysis identified serum C1q-APN/Total-APN ratio and hypertension as significant and independent determinants of CAD. A high serum C1q-APN/Total-APN ratio was associated with 3.965-fold increase in CAD prevalence. Conclusions. High serum C1q-APN/Total-APN ratio correlates with CAD in T2DM. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：578 / 585

页数：8

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