Click Crosslinked Chitosan/Gold Nanocomposite Hydrogels

被引：25

作者：

Garcia-Astrain, Clara ^{[1
]}

Hernandez, Rebeca ^{[2
]}

Guaresti, Olatz ^{[1
]}

Fruk, Ljiljana ^{[3
]}

Mijangos, Carmen ^{[2
]}

Eceiza, Arantxa ^{[1
]}

Gabilondo, Nagore ^{[1
]}

机构：

[1] Univ Basque Country, Engn Coll Gipuzkoa, Dept Chem & Environm Engn, Mat Technol Grp, Pza Europa 1, Donostia San Sebastian 20018, Spain

[2] CSIC, Inst Polymer Sci & Technol, Juan Cierva 3, Madrid 28006, Spain

[3] Univ Cambridge, Dept Chem Engn & Biotechnol, Pembroke St, Cambridge CB2 3RA, England

来源：

MACROMOLECULAR MATERIALS AND ENGINEERING | 2016年 / 301卷 / 11期

关键词：

bionanocomposites; chitosan modifications; click chemistry; Diels-Alder polymers; hydrogels; FUNCTIONALIZED GOLD NANOPARTICLES; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; RHEOLOGICAL PROPERTIES; CHEMISTRY; LINKING; BIOHYDROGELS; BIOMATERIALS;

D O I：

10.1002/mame.201600247

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Preparation of novel nanocomposite hydrogels opens up new avenues to next generation of biocompatible materials to be used in bioengineering and drug delivery. Toward this goal, chitosan nanocomposite hydrogels using click chemistry inspired cross-linking are prepared. To enable this, Diels-Alder reaction of furan-containing chitosan and maleimide-coated gold nanoparticles is employed. The viscoelastic properties of the obtained nanocomposites as well as the effect of the nanoparticles as cross-linkers are studied, indicating that they play significant role in hydrogel formation and stability. Nanoparticle-enriched hydrogels are also found to demonstrate pH-sensitivity therefore showing their potential for future biosensing applications.

引用

页码：1295 / 1300

页数：6

共 30 条

[1] Biohydrogels with magnetic nanoparticles as crosslinker: Characteristics and potential use for controlled antitumor drug-delivery [J].