Cholesterol: An Achilles' Heel for Glioblastoma?

被引：11

作者：

An, Zhenyi ^{[1
,2
,3
,4
]}

Weise, William A. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Brain Tumor Res Ctr, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pediat, Brain Tumor Res Ctr, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Neurosurg, Brain Tumor Res Ctr, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA

来源：

CANCER CELL | 2016年 / 30卷 / 05期

关键词：

LXR; RECEPTOR; AGONIST;

D O I：

10.1016/j.ccell.2016.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Villa et al. report that survival of glioblastoma cells is dependent on uptake of cholesterol. A synthetic agonist of the Liver X receptor depleted cholesterol in GBM cells, slowing growth of GBM xenografts.

引用

页码：653 / 654

页数：2

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