Vitamin B12 catalyzed radical cyclizations of arylalkenes

被引:29
|
作者
McGinley, CM [1 ]
Relyea, HA [1 ]
van der Donk, WA [1 ]
机构
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
关键词
vitamin B-12; radical cyclization; arylalkenes;
D O I
10.1055/s-2005-932588
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The use of vitamin B-12 for synthetic organic transformations has been extensively studied. Herein, we report the intra-molecular cyclization reaction of a series of arylalkene substrates catalyzed by vitamin B-12. These reactions proceed in good yields in environmentally benign solvents and do not require the use of a toxic heavy metal catalyst. Variation of the reaction pH call predictably after the product distribution.
引用
收藏
页码:211 / 214
页数:4
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