Anti-inflammatory Activity of Chemical Constituents Isolated from Peristrophe roxburghiana

被引：0
作者：
Yang, Zhaojun [1 ]
Zhang, Yunhui [1 ]
Yao, Xiaoqing [2 ]
Gao, Wenyuan [1 ]
Jin, Xinghua
机构：
[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
[2] Tianjin Chase Sun Pharmaceut Co Ltd, Tianjin 301700, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 09期
关键词：
Anti-inflammatory; Chemical constituents; Cytokines assay; Peristrophe roxburghiana;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A phytochemical investigation on Peristrophe roxburghiana (Schult.) Brem. resulted in the isolation of 11 compounds, identified as beta-sitosterol (1), beta-daucosterol (2), coumarin (3), 1-octadecanol (4), allantoin (5), lupeol ( 6), oleanolic acid (7), 3-acetyl oleanolic acid (8), cyanidin (9), cyanidin-3-O-beta-D-glucoside (10), peristrophine (11) by analysis of spectroscopic data and comparison with literature. Anti-inflammatory activity of these compounds was carried out in lipopolysaccharide (LPS)-simulated RAW 264.7 cells and carrageenan-induced inflammation on BALB/c mice. Rats and cell treated with PR and eight compounds showed significant (p<0.05) anti-inflammatory effects as evidence from normal cytokines TNF-alpha, IL-1 beta, and IL-6 levels. Significantly anti-inflammatory activity of compounds 3, 8 and 11 is reported for the first time.
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收藏
页码：1279 / 1284
页数：6
相关论文
共 31 条
[21]   Effects of triterpenes on the immune system [J].
Rios, Jose-Luis .
JOURNAL OF ETHNOPHARMACOLOGY, 2010, 128 (01) :1-14
[22]   Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats [J].
Rummel, Christoph ;
Gerstberger, Ruediger ;
Roth, Joachim ;
Huebschle, Thomas .
CYTOKINE, 2011, 56 (03) :739-748
[23]   Aliphatics from Peristrophe bicalyculata [J].
Singh, RS ;
Pandey, RP ;
Singh, BK ;
Singh, RG .
FITOTERAPIA, 2000, 71 (01) :80-81
[24]   Natural phenoxazine alkaloids from Peristrophe bivalvis (L.) Merr [J].
Trinh Thi Thuy ;
Tran Hoai Lam ;
Nguyen Thi Thanh Huong ;
Le Thi Hong Nhung ;
Pham Thi Ninh ;
Nguyen Thi Hoang Anh ;
Tran Thi Phuong Thao ;
Tran Van Sung .
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2012, 44 :205-207
[25]   The triterpenoid lupeol attenuates allergic airway inflammation in a murine model [J].
Vasconcelos, J. F. ;
Teixeira, M. M. ;
Barbosa-Filho, J. M. ;
Lucio, A. S. S. C. ;
Almeida, J. R. G. S. ;
de Queiroz, L. P. ;
Ribeiro-dos-Santos, R. ;
Soares, M. B. P. .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2008, 8 (09) :1216-1221
[26]  
Vasqueza Y.-R., 2000, INT J BIOCHEM CELL B, V32, P833
[27]   CONSTITUENTS OF PERITROPHE-JAPONICA (THUNB) BREMK [J].
WANG, CC ;
KUOH, CS ;
WU, TS .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1992, 39 (04) :351-353
[28]  
WEI X, 1989, Acta Botanica Yunnanica, V11, P476
[29]  
Yao Huan-Kai, 2010, Zhong Yao Cai, V33, P1093
[30]   Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin [J].
Zhou, Zhou ;
Nair, Muraleedharan G. ;
Claycombe, Kate J. .
PHYTOMEDICINE, 2012, 19 (10) :878-881
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