Anti-inflammatory Activity of Chemical Constituents Isolated from Peristrophe roxburghiana

被引：0

作者：

Yang, Zhaojun ^{[1
]}

Zhang, Yunhui ^{[1
]}

Yao, Xiaoqing ^{[2
]}

Gao, Wenyuan ^{[1
]}

Jin, Xinghua

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Chase Sun Pharmaceut Co Ltd, Tianjin 301700, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 09期

关键词：

Anti-inflammatory; Chemical constituents; Cytokines assay; Peristrophe roxburghiana;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A phytochemical investigation on Peristrophe roxburghiana (Schult.) Brem. resulted in the isolation of 11 compounds, identified as beta-sitosterol (1), beta-daucosterol (2), coumarin (3), 1-octadecanol (4), allantoin (5), lupeol ( 6), oleanolic acid (7), 3-acetyl oleanolic acid (8), cyanidin (9), cyanidin-3-O-beta-D-glucoside (10), peristrophine (11) by analysis of spectroscopic data and comparison with literature. Anti-inflammatory activity of these compounds was carried out in lipopolysaccharide (LPS)-simulated RAW 264.7 cells and carrageenan-induced inflammation on BALB/c mice. Rats and cell treated with PR and eight compounds showed significant (p<0.05) anti-inflammatory effects as evidence from normal cytokines TNF-alpha, IL-1 beta, and IL-6 levels. Significantly anti-inflammatory activity of compounds 3, 8 and 11 is reported for the first time.

引用

页码：1279 / 1284

页数：6

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