The mannose receptor

被引：427

作者：

Martinez-Pomares, Luisa ^{[1
]}

机构：

[1] Univ Nottingham, Fac Med & Hlth Sci, Queens Med Ctr, Nottingham NG7 2UH, England

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2012年 / 92卷 / 06期

基金：

英国医学研究理事会;

关键词：

Lectin receptor; antigen presentation; macrophages; dendritic cells; mouse; human; endocytosis; glycosylation; CYSTEINE-RICH DOMAIN; TUMOR-ASSOCIATED MACROPHAGES; ANTIGEN CROSS-PRESENTATION; HUMAN DENDRITIC CELLS; ENDOTHELIAL-CELLS; LIGAND-BINDING; STEADY-STATE; IN-VITRO; METALLOPHILIC MACROPHAGES; GLYCOSYLATION INFLUENCES;

D O I：

10.1189/jlb.0512231

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized ability to modulate cellular activation. This review provides an update of the latest developments in the field. It discusses how MR biology might be affected by glycosylation and proteolytic processing, MR involvement in antigen delivery, and the potential contribution of MR to T cell differentiation and cellular activation. Further understanding of these areas will, no doubt, inform the design of novel, therapeutic tools for improved vaccination, control of inflammation, and tumor chemotherapy, which will benefit from exploiting MR-efficient internalization properties and unique pattern of expression. J. Leukoc. Biol. 92: 1177-1186; 2012.

引用

页码：1177 / 1186

页数：10

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