MiRNA as biomarker for uveitis - A systematic review of the literature

被引：19

作者：

Pockar, Sasa ^{[1
]}

Petrovic, Mojca Globocnik ^{[1
,3
]}

Peterlin, Borut ^{[2
]}

Valentincic, Natasa Vidovic ^{[1
,3
]}

机构：

[1] Univ Med Ctr Ljubljana, Hosp Eye, Ljubljana, Slovenia

[2] Univ Med Ctr Ljubljana, Clin Inst Med Genet, Ljubljana, Slovenia

[3] Univ Ljubljana, Fac Med, Grabloviceva 46, Ljubljana, Slovenia

来源：

GENE | 2019年 / 696卷

关键词：

miRNA; Uveitis; Intracoular inflammation; Biomarkers; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; ETS-1 GENE POLYMORPHISMS; KOYANAGI-HARADA SYNDROME; OCULAR BEHCETS-DISEASE; COPY NUMBER VARIANTS; REGULATORY T-CELLS; MICRORNA-155; EXPRESSION; CIRCULATING MICRORNAS; ALTERED EXPRESSION; MULTIPLE-SCLEROSIS;

D O I：

10.1016/j.gene.2019.02.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: A systematic review of miRNA profiling studies in uveitis. Methods: Literature search strategy - Pubmed central central database, using miRNA/microRNA and intraocular inflammation/uveitis as keywords. Results: We found twenty publications regarding the experimental and clinical use of miRNA in uveitis, published between 2011 and 2018. Conclusion: The publications regarding the role of miRNA in uveitis are very scarce, but provide some valuable information about the potential new mechanisms in uveitis. Some of the identified miRNAs in different uveitis entities could serve as a biomarker of intraocular inflammation. Possible candidate miRNAs could be let-7e, miRNA-1, miR-9-3, miR-20a-5p, miR-23a, mir-29a-3p, miR-140-5p, miR-143, miR-146a and miR-146a-5p, miR155, miR-182 and miR-182-5p, miR-196a2, miR-205, miR-223-3p, miR-301a. MiR-146a, miR-146a-5p, miR155, miR-182, miR-223-3p, have been found to be possibly associated with uveitis disease in both, human and animal species.

引用

页码：162 / 175

页数：14

共 135 条

[1] TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 [J].

Amadi-Obi, Ahjoku ;

Yu, Cheng-Rong ;

Liu, Xuebin ;

Mahdi, Rashid M. ;

Clarke, Grace Levy ;

Nussenblatt, Robert B. ;

Gery, Igal ;

Lee, Yun Sang ;

Egwuagu, Charles E. .

NATURE MEDICINE, 2007, 13 (06) :711-718

[2] Diversifying microRNA sequence and function [J].

Ameres, Stefan L. ;

Zamore, Phillip D. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (08) :475-488

[3] Bias in High-Throughput Analysis of miRNAs and Implications for Biomarker Studies [J].

Backes, Christina ;

Sedaghat-Hamedani, Farbod ;

frese, Karen ;

Hart, Martin ;

Ludwig, Nicole ;

Meder, Benjamin ;

Meese, Eckart ;

Keller, Andreas .

ANALYTICAL CHEMISTRY, 2016, 88 (04) :2088-2095

[4] Toward a combinatorial nature of microRNA regulation in human cells [J].

Balaga, Ohad ;

Friedman, Yitzhak ;

Linial, Michal .

NUCLEIC ACIDS RESEARCH, 2012, 40 (19) :9404-9416

[5] Differential Expression of microRNAs in Francisella tularensis-Infected Human Macrophages: miR-155-Dependent Downregulation of MyD88 Inhibits the Inflammatory Response [J].

Bandyopadhyay, Sarmistha ;

Long, Matthew E. ;

Allent, Lee-Ann H. .

PLOS ONE, 2014, 9 (10)

[6] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[7] Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals [J].

Bazzoni, Flavia ;

Rossato, Marzia ;

Fabbri, Marco ;

Gaudiosi, Daniele ;

Mirolo, Massimiliano ;

Mori, Laura ;

Tamassia, Nicola ;

Mantovani, Alberto ;

Cassatella, Marco A. ;

Locati, Massimo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5282-5287

[8] Identification of hundreds of conserved and nonconserved human microRNAs [J].

Bentwich, I ;

Avniel, A ;

Karov, Y ;

Aharonov, R ;

Gilad, S ;

Barad, O ;

Barzilai, A ;

Einat, P ;

Einav, U ;

Meiri, E ;

Sharon, E ;

Spector, Y ;

Bentwich, Z .

NATURE GENETICS, 2005, 37 (07) :766-770

[9] MicroRNAs, new effectors and regulators of NF-κB [J].

Boldin, Mark P. ;

Baltimore, David .

IMMUNOLOGICAL REVIEWS, 2012, 246 :205-220

[10] miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice [J].

Boldin, Mark P. ;

Taganov, Konstantin D. ;

Rao, Dinesh S. ;

Yang, Lili ;

Zhao, Jimmy L. ;

Kalwani, Manorama ;

Garcia-Flores, Yvette ;

Luong, Mui ;

Devrekanli, Asli ;

Xu, Jessica ;

Sun, Guizhen ;

Tay, Jia ;

Linsley, Peter S. ;

Baltimore, David .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (06) :1189-1201

← 1 2 3 4 5 6 7 8 9 10 →