Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

被引：55

作者：

Sen, Alaattin ^{[1
]}

机构：

[1] Abdullah Gul Univ, Fac Life & Nat Sci, Dept Mol Biol & Genet, Sumer Campus, TR-38080 Kayseri, Turkey

来源：

WORLD JOURNAL OF CLINICAL CASES | 2020年 / 8卷 / 10期

关键词：

Oleanolic acid; Prophylactic; Anti-inflammatory; Anti-diabetics; Neuroprotective; Hepatoprotective; NF-KAPPA-B; ALLERGIC ENCEPHALOMYELITIS MODEL; COLORECTAL-CANCER ANGIOGENESIS; IN-VITRO; BARDOXOLONE METHYL; MULTIPLE-SCLEROSIS; URSOLIC ACID; BIOLOGICAL EVALUATION; OXIDATIVE STRESS; LIVER-INJURY;

D O I：

10.12998/wjcc.v8.i10.1767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles in various diseases such as ulcerative colitis, multiple sclerosis, metabolic disorders, diabetes, hepatitis and different cancers. This review assembles and presents the latestin vivoreports on the impacts of OA and OA derivatives from various plant sources and the biological mechanisms of OA activities. Thus, this review presents sufficient data proposing that OA and its derivatives are potential alternative and complementary therapies for the treatment and management of several diseases.

引用

页码：1767 / 1792

页数：26

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