The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases

被引：37

作者：

Yang, Yang ^{[1
,2
]}

Hu, Wei ^{[1
]}

Jiang, Shuai ^{[3
]}

Wang, Bodong ^{[1
]}

Li, Yue ^{[1
]}

Fan, Chongxi ^{[4
]}

Di, Shouyin ^{[4
]}

Ma, Zhiqiang ^{[4
]}

Lau, Wayne Bond ^{[5
]}

Qu, Yan ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China

[2] Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Dept Aerosp Med, Xian 710032, Shaanxi, Peoples R China

[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian 710038, Peoples R China

[5] Thomas Jefferson Univ Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2015年 / 1852卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Adiponectin; Cerebrovascular diseases; Neurodegenerative diseases; MOLECULAR-WEIGHT ADIPONECTIN; NEUROBLASTOMA SH-SY5Y CELLS; NITRIC-OXIDE SYNTHASE; PLASMA ADIPONECTIN; ISCHEMIC-STROKE; CEREBRAL-ISCHEMIA; SERUM ADIPONECTIN; CIRCULATING ADIPONECTIN; COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID;

D O I：

10.1016/j.bbadis.2015.06.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adiponectin is an anti-atherogenic protein secreted by adipose cells that improves insulin sensitivity. Notably, adiponectin receptors are expressed in the brain, suggesting that adiponectin signaling disruption may impact neurologic function. Recently, studies have demonstrated the association of adiponectin levels with cerebrovascular disorders and neurodegenerative diseases (NDDs), and these results have drawn significant attention. In this review, we discuss the association between the adiponectin levels and the incidence, progression, and prognosis of cerebrovascular disorders and NDDs. We describe the controversial issues surrounding current studies and present our hypothesis concerning the possible mechanism underlying adiponectin function in neurological disorders. Finally, we explicate obstacles preventing clinical adiponectin administration, including available routes of drug delivery and the central nervous system regulation of adiponectin. Collectively, the data assembled herein serve as a comprehensive reference regarding the role of adiponectin in neurological disorders to support the future clinical potential of adiponectin as a therapeutic agent. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1887 / 1894

页数：8

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