The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases

被引:37
作者
Yang, Yang [1 ,2 ]
Hu, Wei [1 ]
Jiang, Shuai [3 ]
Wang, Bodong [1 ]
Li, Yue [1 ]
Fan, Chongxi [4 ]
Di, Shouyin [4 ]
Ma, Zhiqiang [4 ]
Lau, Wayne Bond [5 ]
Qu, Yan [1 ]
机构
[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China
[2] Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Dept Aerosp Med, Xian 710032, Shaanxi, Peoples R China
[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian 710038, Peoples R China
[5] Thomas Jefferson Univ Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2015年 / 1852卷 / 09期
基金
中国国家自然科学基金;
关键词
Adiponectin; Cerebrovascular diseases; Neurodegenerative diseases; MOLECULAR-WEIGHT ADIPONECTIN; NEUROBLASTOMA SH-SY5Y CELLS; NITRIC-OXIDE SYNTHASE; PLASMA ADIPONECTIN; ISCHEMIC-STROKE; CEREBRAL-ISCHEMIA; SERUM ADIPONECTIN; CIRCULATING ADIPONECTIN; COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID;
D O I
10.1016/j.bbadis.2015.06.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adiponectin is an anti-atherogenic protein secreted by adipose cells that improves insulin sensitivity. Notably, adiponectin receptors are expressed in the brain, suggesting that adiponectin signaling disruption may impact neurologic function. Recently, studies have demonstrated the association of adiponectin levels with cerebrovascular disorders and neurodegenerative diseases (NDDs), and these results have drawn significant attention. In this review, we discuss the association between the adiponectin levels and the incidence, progression, and prognosis of cerebrovascular disorders and NDDs. We describe the controversial issues surrounding current studies and present our hypothesis concerning the possible mechanism underlying adiponectin function in neurological disorders. Finally, we explicate obstacles preventing clinical adiponectin administration, including available routes of drug delivery and the central nervous system regulation of adiponectin. Collectively, the data assembled herein serve as a comprehensive reference regarding the role of adiponectin in neurological disorders to support the future clinical potential of adiponectin as a therapeutic agent. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:1887 / 1894
页数:8
相关论文
共 50 条
  • [21] Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
    Rim, Chan
    You, Min-Jung
    Nahm, Minyeop
    Kwon, Min-Soo
    TRANSLATIONAL NEURODEGENERATION, 2024, 13 (01)
  • [22] The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases
    Zedde, Marialuisa
    Pascarella, Rosario
    BRAIN SCIENCES, 2024, 14 (10)
  • [23] Adiponectin and glomerular diseases
    Hou, Jie
    Xu, Ying
    Sun, Weixia
    Gao, Pujun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (01): : 1179 - 1185
  • [24] Adiponectin in Autoimmune Diseases
    Toussirot, E.
    Binda, D.
    Gueugnon, C.
    Dumoulin, G.
    CURRENT MEDICINAL CHEMISTRY, 2012, 19 (32) : 5474 - 5480
  • [25] The Role of Adiponectin in Development and Progression of Cardiovascular Diseases
    Kobalava, Zh. D.
    Villewalde, S. V.
    Isikova, Kh. V.
    KARDIOLOGIYA, 2009, 49 (01) : 51 - 58
  • [26] Editorial: The role of microglia in the pathogenesis of neurodegenerative diseases
    Qin, Qi
    Wang, Meng
    Li, Huiliang
    Xu, Zhiqing David
    Tang, Yi
    FRONTIERS IN AGING NEUROSCIENCE, 2023, 14
  • [27] Immunotherapy: An emerging treatment option for neurodegenerative diseases
    Mukherjee, Abhiyanta
    Biswas, Soumojit
    Roy, Ipsita
    DRUG DISCOVERY TODAY, 2024, 29 (05)
  • [28] THE ROLE OF CLEARANCE IN NEURODEGENERATIVE DISEASES
    Brennan, Georgia s.
    Thompson, Travis b.
    Oliveri, Hadrien
    Rognes, Marie e.
    Goriely, Alain
    SIAM JOURNAL ON APPLIED MATHEMATICS, 2024, 84 (03) : S172 - S198
  • [29] The role of ferroptosis in neurodegenerative diseases
    Fei, Yifan
    Ding, Yifei
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2024, 18
  • [30] Role of Neddylation in Neurodegenerative Diseases
    Govindarajulu, Manoj
    Ramesh, Sindhu
    Shankar, Tharanth
    Kora, Murali Krishna
    Moore, Timothy
    Dhanasekaran, Muralikrishnan
    Gallart-Palau, Xavier
    NEUROSCI, 2022, 3 (04): : 533 - 545