Cycloartane-Type Triterpenes from the Leaves of Homonoia riparia with VEGF-Induced Angiogenesis Inhibitory Activity

被引：12

作者：

Lee, Iksoo ^{[1
]}

Kim, Junghyun ^{[1
]}

Kim, Young Sook ^{[1
]}

Yoo, Nam Hee ^{[2
]}

Kim, Chan-Sik ^{[1
]}

Jo, Kyuhyung ^{[1
]}

Kim, Joo-Hwan ^{[3
]}

Tran The Bach ^{[4
]}

Kim, Jin Sook ^{[1
]}

机构：

[1] Korea Inst Oriental Med, Herbal Med Res Div, Taejon 305811, South Korea

[2] Int Ginseng & Herb Res Inst, Guemsan 312804, South Korea

[3] Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea

[4] Vietnam Acad Sci & Technol, Inst Ecol & Biol Resources, Dept Bot, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 07期

关键词：

ENDOTHELIAL GROWTH-FACTOR; 3,4-SECO-CYCLOARTANE TRITERPENES; GLYCOSIDES;

D O I：

10.1021/np300224k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new cycloartane-type triterpenes (1-6), 24-methylenecydoartane-3 beta,6 beta,7 beta-triol (1), 24-methylenecycloartane-3 beta,6 beta,7 beta,16 beta-tetraol (2), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol (3), 24-methylenecycloartane-3 beta,7 beta,16 beta-triol 3-O-beta-D-xylopyranoside (4), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol 3-O-beta-D-xylopyranoside (5), and 24-methylenecycloartane-3 beta,6 beta,7 beta-triol 3-O-beta-D-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartarie-3 beta,6 beta,7 beta,16 beta-tetraol 3-O-beta-D-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated.

引用

页码：1312 / 1318

页数：7

共 21 条

[1] Bedir E, 2000, BIOL PHARM BULL, V23, P834, DOI 10.1248/bpb.23.834
[2] CYCLOARTANE TRITERPENOIDS
BOAR, RB
ROMER, CR
[J]. PHYTOCHEMISTRY, 1975, 14 (5-6) : 1143 - 1146
[3] Triterpenoids from Tillandsia fasciculata
Cantillo-Ciau, Z
Brito-Loeza, W
Quijano, L
[J]. JOURNAL OF NATURAL PRODUCTS, 2001, 64 (07): : 953 - 955
[4] Che R., 2009, 3 MILIT MED U, V31, P2275
[5] TERPENOIDS .51. ISOLATION OF SOME NEW CYCLOPROPANE-CONTAINING TRITERPENES FROM SPANISH MOSS (TILLANDSIA USNEOIDES, L)
DJERASSI, C
MCCRINDLE, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1962, (10): : 4034 - &
[6] DVORAK HF, 1995, AM J PATHOL, V146, P1029
[7] The biology of vascular endothelial growth factor
Ferrara, N
DavisSmyth, T
[J]. ENDOCRINE REVIEWS, 1997, 18 (01) : 4 - 25
[8] ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE
FOLKMAN, J
[J]. NATURE MEDICINE, 1995, 1 (01) : 27 - 31
[9] CYCLOARTANE TRITERPENE GLYCOSIDES FROM ASTRAGALUS-TRIGONUS
GARIBOLDI, P
PELIZZONI, F
TATO, M
VEROTTA, L
ELSEBAKHY, N
ASAAD, AM
ABDALLAH, RM
TOAIMA, SM
[J]. PHYTOCHEMISTRY, 1995, 40 (06) : 1755 - 1760
[10] Genipatriol, a new cycloartane triterpene from Genipa spruceana
Hossain, CF
Jacob, MR
Clark, AM
Walker, LA
Nagle, DG
[J]. JOURNAL OF NATURAL PRODUCTS, 2003, 66 (03): : 398 - 400

← 1 2 3 →