EPs® 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells

被引：0

作者：

Beil, W. ^{[1
]}

Kilian, P. ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Pharmacol, D-30625 Hannover, Germany

来源：

PHYTOMEDICINE | 2007年 / 14卷

关键词：

Pelargonium sidoides; Helicobacter pylori; Adhesion; Gastric epithelial cells;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Helicobacter pylori specifically adheres to gastric host cells, mainly based on carbohydrate-mediated cell-cell interaction. The extract of Pelargonium sidoides roots (EPs (R) 7630), 1 South African herbal remedy, is currently used to treat acute bronchitis. EPs (R) 7630 prevents bacteria from attaching to cell membranes. Therefore, the ability of EPs (R) 7630 to interfere with H. pylori growth and adhesion to gastric epithelial cells (AGS cells) was tested in vitro. EPs (R) 7630 inhibited H. pylori growth and with higher potency adhesion to gastric AGS cells. EPs (R) 7630 (50 and 100 mu g/ml) reduced bacterial count attached to AGS cells by 77% and 91%, respectively. The results suggest that the mode of action of EPs (R) 7630 is mainly related to its anti-adhesive activity. (C) 2006 Elsevier GmbH. All rights reserved.

引用

页码：5 / 8

页数：4

共 20 条

[1] BROWN DJ, 2004, HERBAL GRAM, V63, P17
[2] Eradication of Helicobacter pylori with a Chinese herbal medicine without emergence of resistant colonies
Higuchi, K
Arakawa, T
Ando, K
Fujiwara, Y
Uchida, T
Kuroki, T
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (05) : 1419 - 1420
[3] HIRMO S, 1995, FEMS IMMUNOL MED MIC, V10, P301, DOI 10.1016/0928-8244(94)00081-4
[4] Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme
Kayser, O
Kolodziej, H
[J]. PLANTA MEDICA, 1997, 63 (06) : 508 - 510
[5] Pharmacological profile of extracts of Pelargonium sidoides and their constituents
Kolodziej, H
Kayser, O
Radtke, OA
Kiderlen, AF
Koch, E
[J]. PHYTOMEDICINE, 2003, 10 : 18 - 24
[6] Pathogenesis of Helicobacter pylori infection
Lamarque, D
Peek, RM
[J]. HELICOBACTER, 2003, 8 : 21 - 30
[7] Latté KP, 2000, Z NATURFORSCH C, V55, P528
[8] Inhibition of Helicobacter pylori adhesion to human gastric adenocarcinoma epithelial cells by acidic polysaccharides from Artemisia capillaris and Panax ginseng
Lee, JH
Park, EK
Uhm, CS
Chung, MS
Kim, KH
[J]. PLANTA MEDICA, 2004, 70 (07) : 615 - 619
[9] In vitro anti-Helicobacter pylori action of 30 Chinese herbel medicines used to treat ulcer diseases
Li, Y
Xu, C
Zhang, QA
Liu, JY
Tan, RX
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2005, 98 (03) : 329 - 333
[10] MARSHALL B, 1983, LANCET, V1, P1273

← 1 2 →