Progress in the identification of plasma biomarkers of colorectal cancer

被引：16

作者：

Coghlin, Caroline ^{[1
]}

Murray, Graeme I. ^{[2
]}

机构：

[1] NHS Grampian, Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland

[2] Univ Aberdeen, Sch Med & Dent, Div Appl Med, Aberdeen, Scotland

来源：

PROTEOMICS | 2013年 / 13卷 / 15期

关键词：

Biomarker; Biomedicine; Colorectal adenoma; Colorectal cancer; Screening;

D O I：

10.1002/pmic.201300245

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteomic analysis of human tissue and plasma samples has been a useful tool in recent years for the identification of potential biomarkers to aid in the early diagnosis of colorectal cancer. However, biomarkers relating to the crucial transition between adenomatous lesions and invasive colorectal malignancy have not previously been described. Proteomics 2013, 13, 2361-2374) attempts to address this issue. Using plasma samples from age-matched patients with colorectal adenomas or invasive disease this group identified a range of plasma proteins and cytokines that were differentially expressed. This information not only provides insights into the biology of the adenoma to carcinoma progression sequence but it also represents a step towards the goal of achieving diagnostically accurate and clinically acceptable biomarkers in early colorectal cancer.

引用

页码：2227 / 2228

页数：2

共 9 条

[1] Candidate biomarker verification: Critical examination of a serum protein pattern for human colorectal cancer [J].

Albrethsen, Jakob ;

Bogebo, Rikke ;

Moller, Christian H. ;

Olsen, Jesper A. ;

Raskov, Hans H. ;

Gammeltoft, Steen .

PROTEOMICS CLINICAL APPLICATIONS, 2012, 6 (3-4) :182-189

[2] Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients [J].

Choi, Jung-Won ;

Liu, Hao ;

Shin, Dong Hoon ;

Yu, Gyeong Im ;

Hwang, Jae Seok ;

Kim, Eun Soo ;

Yun, Jong Won .

PROTEOMICS, 2013, 13 (15) :2361-2374

[3] Following the protein biomarker trail to colorectal cancer [J].

Coghlin, Caroline ;

Murray, Graeme I. .

COLORECTAL CANCER, 2012, 1 (02) :93-96

[4] Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications [J].

de Wit, Meike ;

Fijneman, Remond J. A. ;

Verheul, Henk M. W. ;

Meijer, Gerrit A. ;

Jimenez, Connie R. .

CLINICAL BIOCHEMISTRY, 2013, 46 (06) :466-479

[5] Proximal Fluid Proteome Profiling of Mouse Colon Tumors Reveals Biomarkers for Early Diagnosis of Human Colorectal Cancer [J].

Fijneman, Remond J. A. ;

de Wit, Meike ;

Pourghiasian, Maral ;

Piersma, Sander R. ;

Pham, Thang V. ;

Warmoes, Marc O. ;

Lavaei, Mehrdad ;

Piso, Chloe ;

Smit, Fiona ;

Delis-van Diemen, Pien M. ;

van Turenhout, Sietze T. ;

Droste, Jochim S. Terhaar Sive ;

Mulder, Chris J. J. ;

Blankenstein, Marinus A. ;

Robanus-Maandag, Els C. ;

Smits, Ron ;

Fodde, Riccardo ;

van Hinsbergh, Victor W. M. ;

Meijer, Gerrit A. ;

Jimenez, Connie R. .

CLINICAL CANCER RESEARCH, 2012, 18 (09) :2613-2624

[6] Mathematical Model Identifies Blood Biomarker-Based Early Cancer Detection Strategies and Limitations [J].

Hori, Sharon S. ;

Gambhir, Sanjiv S. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (109)

[7] The Proteomics of Colorectal Cancer: Identification of a Protein Signature Associated with Prognosis [J].

O'Dwyer, Donna ;

Ralton, Lynda D. ;

O'Shea, Aisling ;

Murray, Graeme I. .

PLOS ONE, 2011, 6 (11)

[8]

Ralton LD, 2010, CURR PROTEOMICS, V7, P212

[9] The price of autonomy: should we off er individuals a choice of colorectal cancer screening strategies? [J].

van Dam, Leonie ;

Kuipers, Ernst J. ;

Steyerberg, Ewout W. ;

van Leerdam, Monique E. ;

de Beaufort, Inez D. .

LANCET ONCOLOGY, 2013, 14 (01) :E38-E46

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