Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

被引：201

作者：

Jiang, Qian ^{[1
,2
,3
]}

Chen, Jiashun ^{[1
]}

Yang, Chengbo ^{[3
]}

Yin, Yulong ^{[1
]}

Yao, Kang ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab Proc, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100043, Peoples R China

[3] Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada

来源：

BIOMED RESEARCH INTERNATIONAL | 2019年 / 2019卷

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

STAPHYLOCOCCUS-AUREUS STRAINS; AERUGINOSA BIOFILM FORMATION; ACYL HOMOSERINE LACTONES; ENOYL-ACP REDUCTASE; PSEUDOMONAS-AERUGINOSA; VIRULENCE FACTORS; AHL-LACTONASE; INHIBITORS; AGR; GENES;

D O I：

10.1155/2019/2015978

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.

引用

页数：15

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