Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

被引：201

作者：

Jiang, Qian ^{[1
,2
,3
]}

Chen, Jiashun ^{[1
]}

Yang, Chengbo ^{[3
]}

Yin, Yulong ^{[1
]}

Yao, Kang ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab Proc, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100043, Peoples R China

[3] Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada

来源：

BIOMED RESEARCH INTERNATIONAL | 2019年 / 2019卷

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

STAPHYLOCOCCUS-AUREUS STRAINS; AERUGINOSA BIOFILM FORMATION; ACYL HOMOSERINE LACTONES; ENOYL-ACP REDUCTASE; PSEUDOMONAS-AERUGINOSA; VIRULENCE FACTORS; AHL-LACTONASE; INHIBITORS; AGR; GENES;

D O I：

10.1155/2019/2015978

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.

引用

页数：15

共 122 条

[31] Analysis of the genetic variability of genes encoding the RNA III-activating components Agr and TRAP in a population of Staphylococcus aureus strains isolated from cows with mastitis [J].

Gilot, P ;

Lina, G ;

Cochard, T ;

Poutrel, B .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (11) :4060-4067

[32] Quorum quenching: role in nature and applied developments [J].

Grandclement, Catherine ;

Tannieres, Melanie ;

Morera, Solange ;

Dessaux, Yves ;

Faure, Denis .

FEMS MICROBIOLOGY REVIEWS, 2016, 40 (01) :86-116

[33] Acylase-containing polyurethane coatings with anti-biofilm activity [J].

Grover, Navdeep ;

Plaks, Joseph G. ;

Summers, Samantha R. ;

Chado, Garrett R. ;

Schurr, Michael J. ;

Kaar, Joel L. .

BIOTECHNOLOGY AND BIOENGINEERING, 2016, 113 (12) :2535-2543

[34] Effect of Quorum Quenching Lactonase in Clinical Isolates of Pseudomonas aeruginosa and Comparison with Quorum Sensing Inhibitors [J].

Guendouze, Assia ;

Plener, Laure ;

Bzdrenga, Janek ;

Jacquet, Pauline ;

Remy, Benjamin ;

Elias, Mikael ;

Lavigne, Jean-Philippe ;

Daude, David ;

Chabriere, Eric .

FRONTIERS IN MICROBIOLOGY, 2017, 8

[35] Small Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents [J].

Guo, Min ;

Gamby, Sonja ;

Zheng, Yue ;

Sintim, Herman O. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (09) :17694-17728

[36] Acyl Homoserine Lactones from Culture Supernatants of Pseudomonas aeruginosa Accelerate Host Immunomodulation [J].

Gupta, Ravi Kumar ;

Chhibber, Sanjay ;

Harjai, Kusum .

PLOS ONE, 2011, 6 (06)

[37] China in action: national strategies to combat against emerging infectious diseases [J].

Han, Min ;

Gu, Jinhui ;

Gao, George F. ;

Liu, William J. .

SCIENCE CHINA-LIFE SCIENCES, 2017, 60 (12) :1383-1385

[38] Autoinducer 2 activity in Escherichia coli culture supernatants can be actively reduced despite maintenance of an active synthase, LuxS [J].

Hardie, KR ;

Cooksley, C ;

Green, AD ;

Winzer, K .

MICROBIOLOGY-SGM, 2003, 149 :715-728

[39] Pseudomonas aeruginosa: So many virulence factors, so little time [J].

Hauser, Alan R. .

CRITICAL CARE MEDICINE, 2011, 39 (09) :2193-2194

[40]

Hentzer M, 2003, J CLIN INVEST, V112, P1300, DOI [10.1172/JCI200320074, 10.1172/JCI20074]

← 1 2 3 4 5 6 7 8 9 10 →