Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

被引:201
作者
Jiang, Qian [1 ,2 ,3 ]
Chen, Jiashun [1 ]
Yang, Chengbo [3 ]
Yin, Yulong [1 ]
Yao, Kang [1 ]
机构
[1] Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab Proc, Beijing, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100043, Peoples R China
[3] Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada
基金
美国国家科学基金会; 中国国家自然科学基金;
关键词
STAPHYLOCOCCUS-AUREUS STRAINS; AERUGINOSA BIOFILM FORMATION; ACYL HOMOSERINE LACTONES; ENOYL-ACP REDUCTASE; PSEUDOMONAS-AERUGINOSA; VIRULENCE FACTORS; AHL-LACTONASE; INHIBITORS; AGR; GENES;
D O I
10.1155/2019/2015978
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.
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页数:15
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