The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

被引：84
作者：
Bottomley, Matthew J. [1 ]
Thomson, Jason [2 ]
Harwood, Catherine [2 ]
Leigh, Irene [2 ]
机构：
[1] Univ Oxford, Nuffield Dept Surg Sci, Transplantat Res & Immunol Grp, Oxford OX3 9DU, England
[2] Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Cell Biol & Cutaneous Res, London E1 2AT, England
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 08期
关键词：
malignancy; cancer; immunology; leucocyte; skin; cutaneous; immunity; SCC; cSCC; squamous cell carcinoma; NONMELANOMA SKIN-CANCER; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; KIDNEY-TRANSPLANT RECIPIENTS; INNATE LYMPHOID-CELLS; NATURAL-KILLER-CELL; LANGERHANS CELLS; ULTRAVIOLET-RADIATION; HUMAN-PAPILLOMAVIRUS; TUMOR MICROENVIRONMENT;
D O I：
10.3390/ijms20082009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. In immunosuppressed populations it is a source of considerable morbidity and mortality due to its enhanced recurrence and metastatic potential. In common with many malignancies, leucocyte populations are both protective against cancer development and also play a role in sculpting' the nascent tumor, leading to loss of immunogenicity and tumor progression. UV radiation and chronic viral carriage may represent unique risk factors for cSCC development, and the immune system plays a key role in modulating the response to both. In this review, we discuss the lessons learned from animal and ex vivo human studies of the role of individual leucocyte subpopulations in the development of cutaneous SCC. We then discuss the insights into cSCC immunity gleaned from studies in humans, particularly in populations receiving pharmacological immunosuppression such as transplant recipients. Similar insights in other malignancies have led to exciting and novel immune therapies, which are beginning to emerge into the cSCC clinical arena.
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页数：22
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