Modality switching between therapy and imaging based on the excitation wavelength dependence of dual-function agents in folic acid-conjugated graphene oxides

被引：2

作者：

Jun, Seung Won ^{[1
]}

Kwon, Junyoung ^{[1
]}

Chun, Soo Kyung ^{[1
]}

Lee, Hyun Ah ^{[2
]}

Lee, Jaebeom ^{[1
]}

Hwang, Dae Youn ^{[2
]}

Dong, Chen-Yuan ^{[3
]}

Kim, Chang-Seok ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Cognomechatron Engn, Busan 46241, South Korea

[2] Pusan Natl Univ, Dept Biomat Sci, Miryang 50463, South Korea

[3] Natl Taiwan Univ, Dept Phys, Taipei 10617, Taiwan

来源：

BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

TARGETED DRUG-DELIVERY; PHOTOTHERMAL THERAPY; ANTICANCER DRUGS; FOLATE RECEPTOR; GOLD NANORODS; CELL THERAPY; NANOPARTICLES; NANOMATERIALS; MICROSCOPY; CANCER;

D O I：

10.1364/BOE.9.000705

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Owing to its near infrared (NIR) absorption, graphene oxide (GO) is promising for both photothermal (PT) therapy and multiphoton (MP) imaging. Novel therapy/imaging modality switching is proposed here based on the selected excitation wavelength of femtosecond (FS) laser. GO-based destruction of cancer cells is demonstrated when the laser power of 800-nm-wavelength FS laser is increased above 7 mW. However, GO-based imaging is mainly monitored without damaging the sample when using 1200-nm wavelength FS laser in the same laser power range. Folic acid (FA) conjugated graphene oxide (FA-GO) was synthesized for selective cancer cell targeting. Dual-function FA-GO-based cancer cell targeting agents were experimentally optimized to enable therapy/imaging modality switching. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：705 / 717

页数：13

共 30 条

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