Blood pressure targets in patients with chronic kidney disease: MDRD and AASK now confirming SPRINT

被引：9

作者：

Sarafidis, Pantelis ^{[1
]}

Loutradis, Charalampos ^{[1
]}

Ortiz, Alberto ^{[2
,3
]}

Ruilope, Luis M. ^{[4
,5
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Nephrol, Hippokrat Hosp, Thessaloniki, Greece

[2] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, FRIAT, Sch Med, Madrid, Spain

[3] REDINREN, Madrid, Spain

[4] Hosp Univ 12 Octubre, Inst Res I 12, Madrid, Spain

[5] Univ Europea Madrid, Sch Doctoral Studies & Res, Madrid, Spain

来源：

CLINICAL KIDNEY JOURNAL | 2020年 / 13卷 / 03期

关键词：

blood pressure targets; chronic kidney disease; end-stage kidney disease; hypertension; mortality; renal outcomes; PROGRESSION; HYPERTENSION; REDUCTION; DIET;

D O I：

10.1093/ckj/sfaa015

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recent American and European hypertension guidelines are not in agreement regarding blood pressure (BP) targets for persons with chronic kidney disease (CKD). Previous analyses from the African American Study on Kidney Disease (AASK) and Modification of Diet in Renal Disease (MDRD) trials suggested that strict BP control confers nephroprotection for patients with proteinuria, but a mortality benefit was not apparent. In contrast, an analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) subpopulation of CKD patients showed a mortality benefit with the systolic blood pressure (SBP)<120mmHg versus the SBP<140 target. A recent analysis of the combined MDRD and AASK cohorts supports previous evidence on nephroprotection but also findings from the SPRINT trial on all-cause mortality benefits of intensive versus usual BP control in individuals with CKD.

引用

页码：287 / 290

页数：4

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