The mTOR Signaling Pathway in Pediatric Neuroblastoma

被引：26

作者：

Mei, Hong ^{[1
]}

Wang, Ye ^{[2
]}

Lin, Zhenyu ^{[2
]}

Tong, Qiangsong ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Pediat Surg, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Ctr Canc, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2013年 / 30卷 / 07期

关键词：

mTOR inhibitors; mTOR pathway; neuroblastoma; pediatric; ACTIVATED PROTEIN-KINASE; GROWTH IN-VITRO; TUBEROUS-SCLEROSIS; TUMOR-SUPPRESSOR; DOWN-REGULATION; CELL-GROWTH; PHOSPHATIDYLINOSITOL; 3-KINASE; MAMMALIAN TARGET; BREAST-CANCER; MYCN PROTEIN;

D O I：

10.3109/08880018.2013.798058

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroblastoma (NB) is the most common extracranial malignant solid tumors of childhood, and the majority of these high-risk tumors is resistant to nearly all the treatments and has a significantly worse outcome. The mammalian target of rapamycin (mTOR) plays a critical role in oncogenesis and cancer progression of many tumors. This review will describe the function of mTOR, its genetic regulation in pediatric neuroblastoma, and its value as a target for inhibition by anticancer agents for patients with NB.

引用

页码：605 / 615

页数：11

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