Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

被引：11
|
作者：
Segala, Diego [1 ,3 ]
Gobbo, Stefano [1 ,3 ]
Pesci, Anna [2 ,3 ]
Martignoni, Guido [2 ,3 ]
Santoro, Angela [4 ]
Angelico, Giuseppe [4 ]
Arciuolo, Damiano [4 ]
Spadola, Saveria [4 ]
Valente, Michele [4 ]
Scambia, Giovanni [4 ,5 ]
Zannoni, Gian Franco [4 ,5 ]
机构：
[1] Pederzoli Hosp, Dept Pathol, Verona, Italy
[2] IRCCS Osped Sacro Cuore Don Calabria, Dept Pathol, Verona, Italy
[3] Univ Verona, Sect Pathol, Dept Diagnost & Publ Hlth, Verona, Italy
[4] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth, Rome, Italy
[5] Univ Cattolica Sacro Cuore, Rome, Italy
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2019年 / 215卷 / 05期
关键词：
Uterine tumor resembling ovarian sex cord tumor; UTROSCT; Tamoxifen; Breast cancer; Imunohistochemistry; ENDOMETRIAL CANCER; RISK;
D O I：
10.1016/j.prp.2019.01.039
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.
引用
收藏
页码：1089 / 1092
页数：4
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