The antimetabolites, such as mitomycin - C or fluorouracil, are currently in,clinical use in ophthalmology. We have studied 24 eyes operated on glaucoma with adjunctive mitomycin - C. The operated patients suffered from neovascular, posttraumatic, congenital, inflammatory, developmental,exfoliative and previously unsuccessfully operated open angle glaucoma. fn 18(75%) eyes normotensy was registrated after operation.