Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties

被引：16

作者：

Castel-Molieres, Marion ^{[1
]}

Conzatti, Guillaume ^{[1
]}

Torrisani, Jerome ^{[2
]}

Rouilly, Antoine ^{[3
]}

Cavalie, Sandrine ^{[1
]}

Carrere, Nicolas ^{[2
]}

Tourrette, Audrey ^{[1
]}

机构：

[1] Univ Paul Sabatier, Fac Pharm, CNRS, INPT,CIRIMAT,Equipe PPB, 35 Chemin Maraichers, F-31062 Toulouse 9, France

[2] Univ Toulouse III Paul Sabatier, CNRS, INSERM,ERL5294,UMR1037, Canc Res Ctr Toulouse CRCT Team Epigenet & Tranla, 2 Ave Hubert Curien, F-31037 Toulouse 1, France

[3] INRA, INP ENSIACET, ENSIACET, Lab Chim Agroind,UMR 1010, 4 Allee Emile Monso,BP 44362, F-31030 Toulouse 4, France

来源：

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING | 2018年 / 38卷 / 01期

关键词：

Chitosan; Alginate; Polyelectrolyte complex; Film; IN-VITRO; MECHANICAL-PROPERTIES; SODIUM ALGINATE; CHITOSAN; DERIVATIVES; FILMS; BIOCOMPATIBILITY; SOLUBILIZATION; SPECTROSCOPY; DEGRADATION;

D O I：

10.1007/s40846-017-0304-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polyelectrolyte complex (PEC) films were prepared from chitosan (CHI) and alginate (ALG) which are polymers of opposite charge. Two homogenization techniques and two ratios of ALG-CHI blends were compared: mechanical agitation under vacuum (ALG-CHI ST) or agitation by high turbulence (ALG-CHI UT) and 50/50 or 63/37 ratios. Surface and structure of PEC films are affected by the homogenization technique while the swelling percentage is only affected by polymer ratio. The homogenization ratio does not seem to influence in vitro cell proliferation. Results show that the UT homogenization technique with a 63/37 ratio, which gives films with a smooth, homogeneous surface and a higher rate of enzymatic resistance, is more efficient for cell proliferation and viability. These first results confirm the potential use of ALG-CHI films for surgery application.

引用

页码：10 / 21

页数：12

共 57 条

[31] In vitro and in vivo degradation behavior of acetylated chitosan porous beads [J].