Gemcitabine and Oxaliplatin, but Not Sorafenib or Paclitaxel, Have a Synergistic Effect with Yttrium-90 in Reducing Hepatocellular Carcinoma and Cholangiocarcinoma Cell Line Viability

被引：8

作者：

Edeline, Julien ^{[1
,3
]}

Coulouarn, Cedric ^{[3
]}

Crouzet, Laurence ^{[1
,3
]}

Pracht, Marc ^{[1
]}

Lepareur, Nicolas ^{[2
,3
]}

Clement, Bruno ^{[3
]}

Garin, Etienne ^{[2
,3
]}

机构：

[1] Ctr Eugene Marquis, Dept Med Oncol, F-35043 Rennes, France

[2] Ctr Eugene Marquis, Dept Nucl Med, F-35043 Rennes, France

[3] INSERM, UMR991, Rennes, France

来源：

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2015年 / 26卷 / 12期

关键词：

IN-VITRO DEMONSTRATION; CANCER; RADIOEMBOLIZATION; CHEMOTHERAPY;

D O I：

10.1016/j.jvir.2015.06.032

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Synergy between yttrium-90 (Y-90) and antineoplastic drugs was investigated. Viability of HepaRG (hepatocellular carcinoma) and HuCCT1 (cholangiocarcinoma) cells was studied through a tetrazolium dye reduction assay. A combination index (CI) was calculated, with CI < 1 denoting synergy and CI > 1 denoting antagonism. In HepaRG cells, gemcitabine showed synergy with Y-90 (CI = 0.70 [95% confidence interval = 0.65-0.75]), whereas oxaliplatin (CI = 1.15 [1.08-1.21]), paclitaxel (CI = 1.26 [1.15-1.37]), and sorafenib (CI = 1.77 [1.65-1.89]) showed antagonism In HuCCT1 cells, gemcitabine (CI = 0.54 [0.50-0.58]) and oxaliplatin (CI = 0.86 [0.82-0.90]) showed synergy with Y-90, whereas paclitaxel (CI = 1.18 [1.09-1.27]) and sorafenib (CI = 1.21 [1.12-1.30]) showed antagonism. These results suggest that gemcitabine and oxaliplatin should be tested in combination with Y-90 radioembolization for treatment of liver cancer.

引用

页码：1874 / 1878

页数：5

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