Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion

被引：58

作者：

Li, Yan ^{[1
,2
]}

Zhang, Peng ^{[3
,4
]}

Choi, Tae-Yong ^{[5
,6
]}

Park, Sook Kyung ^{[7
]}

Park, Hanwool ^{[8
]}

Lee, Eun-Jae ^{[8
]}

Lee, Dongsoo ^{[1
]}

Roh, Junyeop Daniel ^{[1
]}

Mah, Won ^{[7
]}

Kim, Ryunhee ^{[2
]}

Kim, Yangsik ^{[8
]}

Kwon, Harah ^{[2
]}

Bae, Yong Chul ^{[7
]}

Choi, Se-Young ^{[5
,6
]}

Craig, Ann Marie ^{[3
,4
]}

Kim, Eunjoon ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Synapt Brain Dysfunct, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[3] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada

[4] Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2B5, Canada

[5] Seoul Natl Univ, Coll Dent, Dept Physiol, Seoul 110749, South Korea

[6] Seoul Natl Univ, Dent Res Inst, Program BK21, Seoul 110749, South Korea

[7] Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 700412, South Korea

[8] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Taejon 305701, South Korea

来源：

CELL REPORTS | 2015年 / 12卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

PROTEIN-TYROSINE PHOSPHATASES; AUTISM SPECTRUM DISORDERS; ADHESION-LIKE MOLECULES; RICH REPEAT PROTEINS; PTP-SIGMA; INTELLECTUAL DISABILITY; TRANSMEMBRANE PROTEINS; MENTAL-RETARDATION; SPATIAL MEMORY; RECEPTOR;

D O I：

10.1016/j.celrep.2015.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here, we identify an interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that requires the mini-exon B splice insert in LAR-RPTPs. In addition, SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. SALM3 mutant (Salm3(-/-)) mice display markedly reduced excitatory synapse number but normal synaptic plasticity in the hippocampal CA1 region. Salm3(-/-) mice exhibit hypoactivity in both novel and familiar environments but perform normally in learning and memory tests administered. These results suggest that SALM3 regulates excitatory synapse development and locomotion behavior.

引用

页码：1618 / 1630

页数：13

共 67 条

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