Gingival Rhabdomyosarcoma Accompanied by an Immature Myogenic Population Immunore active for α-Smooth Muscle Actin in a Dog

被引：4

作者：

Kimura, M. ^{[1
]}

Suzuki, K. ^{[2
]}

Fujii, Y. ^{[1
]}

Yamamoto, R. ^{[1
]}

Shibutani, M. ^{[1
]}

Mitsumori, K. ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Lab Vet Pathol, Tokyo, Japan

[2] Tokyo Univ Agr & Technol, Lab Vet Toxicol, Tokyo, Japan

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2013年 / 149卷 / 01期

关键词：

dog; gingiva; immunohistochemistry; rhabdomyosarcoma; PLEOMORPHIC RHABDOMYOSARCOMA; DIFFERENTIATION;

D O I：

10.1016/j.jcpa.2012.11.233

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 3-year-old female shih tzu was presented with a white to dark red mass arising from the gingiva. Because of the rapid and invasive growth of the mass, the dog was humanely destroyed. Microscopically, round to polygonal anaplastic cells with strongly eosinophilic cytoplasm grew in an alveolar pattern separated by fibrous stroma. Mitotic figures were numerous. Multinucleated cells and 'strap cells' were observed, but cross striation and glycogen accumulation were absent. Immunohistochemically, the tumour cells were positive for vimentin, desmin, muscle-specific actin and MyoD I, and a small number of tumour cells were positive for a-smooth muscle actin (alpha-SMA). Based on the morphological and immunohistochemical features, the gingival mass was diagnosed as alveolar rhabdomyosarcoma accompanied by alpha-SMA-positive immature myogenic cells. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：48 / 52

页数：5

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